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Shifts in subsurface oxygen transport and consumption patterns in a restored coastal flood plain over five yearsNARA Subscribed
Groundwater dissolved oxygen (DO) variability in coastal systems remains poorly understood despite its importance for biogeochemical cycling and ecosystem modeling. This study investigates temporal variability in groundwater DO and its hydro‐climatic drivers across timescales (hourly to seasonal) in a coastal floodplain at Beaver Creek, Washington, USA, a site transitioning from a freshwater forest to brackish tidal wetland fo...
Comparing phosphatised galleried stereom of Ordovician Cincinnaticrinus to modern Endoxocrinus illustrates preservation by micromoldingNARA Subscribed
Fossil echinoderm ossicles are often occluded by syntaxial overgrowths which obscure stereom. Phosphatized ossicles from insoluble residues show fine microstructure. We investigated phosphatized stereom in Cincinnaticrinus columnals in insoluble residues from the Ordovician around Cincinnati, Ohio USA. Microstructures appeared to be stereom micromolds. We tested this hypothesis by examining residue and thin sections of undisso...
The decline in estrogen following menopause is a major driver of metabolic and immune dysfunction in aging females. While hormone replacement therapy improves many of these outcomes, its clinical use remains limited due to concerns regarding estrogen-sensitive malignancies. Tissue-selective estrogen complexes (TSECs), which combine estrogens with selective estrogen receptor modulators (SERMs) such as tamoxifen (TAM), represent...
Methylation array signals are predictive of chronological age without bisulfite conversionNARA Subscribed
DNA methylation data has been used to make “epigenetic clocks” which attempt to measure chronological and biological aging. These models rely on data derived from bisulfite-based measurements, which exploit a semi-selective deamination and a genomic reference to determine methylation states. We found that non-methylation factors lead to “pseudomethylation” signals that are both confounding of epigenetic clocks and uniquely age...
Sexually selected differences in warbler plumage are related to a putative inversion on the Z chromosomeNARA Subscribed
Large structural variants in the genome, such as inversions, may play an important role in producing population structure and local adaptation to the environment through suppression of recombination. However, relatively few studies have linked inversions to phenotypic traits that are sexually selected and may play a role in reproductive isolation. Here, we found that geographic differences in the sexually selected plumage of a...