D. Herrmann results 69
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Live-cell imaging reveals decreased cAMP in a PFE-associated c.1050-3C>G PTH1R cell modelNARA Subscribed
Primary failure of eruption (PFE) is a rare autosomal disorder provoked by heterozygous mutations in the parathyroid hormone receptor 1 ( PTH1R ) gene. PTH1R is a G protein-coupled receptor (GPCR) which regulates intracellular signaling molecules like cAMP. By using CRISPR/Cas9, the pathogenic PTH1R variant, c.1050-3C>G, was introduced into the periodontal ligament (PDL-hTERT) cell line to investigate molecular mechanisms in a...
The carbon dioxide radical anion as a reductant in water treatment and atmospheric chemistry: a reviewNARA Subscribed
The carbon dioxide radical anion, CO 2 ●− , is a highly reactive radical species involved in the reduction of the CO 2 greenhouse gas, organic synthesis, atmospheric aerosol chemistry, and treatment of halogenated compounds. In recent years, CO 2 ●− has emerged as a strong reductant, or single electron donor. Here we present techniques used to generate CO 2 ●− and we discuss applications to degrading pollutants such as halogen...
A fundamental trade‐off among resilience, resistance, efficiency, and redundancy in tidal wetlandsNARA Subscribed
In an era of change, the survival and adaptability of ecosystems will be tested. An optimal ecosystem would be both resistant and resilient to negative disturbance but also efficient and redundant in its growth when given positive subsidies. However, initial evidence has suggested that these properties cannot all be maximized at the same time, and so we sought to quantitatively assess whether there are fundamental trade‐offs b...
Small-scale coastal fisheries in the Mediterranean often employ gillnets, a widely used gear worldwide. The disadvantages of gillnets in this fishery include high bycatch levels of unwanted species and consequent discards. Moreover, spatial conflict with other gears and dolphin depredation often results in considerable economic loss. Alternative fishing methods are being tested. This study investigated whether, in small-scale...
Observing fish behavior in towed fishing gear—is there an influence of artificial light?NARA Subscribed
Fish behavior is important to consider when developing selective fishing gear. In studies designed to investigate the size selective properties of towed fishing gears such as trawls, fish behavior is mainly documented by underwater video recordings. Because fishing gear can be operated at great depths or in other low light environments, artificial light is often required for underwater recordings. However, artificial light can...
Cefepime versus carbapenems for treatment of AmpC beta-lactamase-producing Enterobacterales bloodstream infectionsNARA Subscribed
Purpose Cefepime is recommended for treating infections caused by AmpC beta-lactamase-producing Enterobacterales (AmpC-PE), though supporting evidence is limited. Therefore, this study compared outcomes associated with cefepime versus carbapenem therapy for bloodstream infections (BSIs) caused by AmpC-PE after phenotypic exclusion of ESBL-co-producing isolates. Methods This retrospective cohort study compared definite cefepime...
Isolating the drivers of the species‐area relationship in experimental habitat islandsNARA Subscribed
Aim Considered one of ecology's laws, the species‐area relationship (SAR) is among the most intensively studied ecological phenomena, yet the mechanisms through which the SAR arises and under what circumstances remain poorly understood. Here, we experimentally test the effects of area alone in the absence of commonly invoked mechanistic drivers of the SAR in both sub‐tidal bay and inter‐tidal marsh habitats. Location Louisiana...
Joint effects of climate, tree size, and year on annual tree growth derived from tree‐ring records of ten globally distributed forestsNARA Subscribed
Tree rings provide an invaluable long‐term record for understanding how climate and other drivers shape tree growth and forest productivity. However, conventional tree‐ring analysis methods were not designed to simultaneously test effects of climate, tree size, and other drivers on individual growth. This has limited the potential to test ecologically relevant hypotheses on tree growth sensitivity to environmental drivers and...