D. Horner results 31
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Introduction In this study we investigate the Suspended Particulate Matter (SPM) source and dynamics in terms of resuspension and advection in the mid field region of Rhine Region Of Freshwater Influence (Rhine-ROFI). In this area of the Rhine-ROFI, the sediment transport mechanisms are governed by the Rhine freshwater plume originating from the Rhine-Meuse estuary and propagating towards the coast in northward direction. Meth...
Recent Advances in Bioanalytical Methods for Quantification and Pharmacokinetic Analyses of Antibody–Drug ConjugatesNARA Subscribed
Antibody–drug conjugates (ADCs) represent a rapidly expanding class of therapeutics, uniquely combining the specificity of monoclonal antibodies with the potency of cytotoxic small-molecule payloads. Due to their inherent structural complexity and heterogeneous composition, accurate characterization and quantification of ADCs pose significant bioanalytical challenges. This review discusses recent advancements in bioanalytical...
We present direct measurements of seafloor ripple dimensions, near-bed mean flow Reynolds stresses and near-bed turbulent sediment fluxes on a sandy inner shelf subjected to strong wave and tidal current forcing. The measurements of ripple dimensions (height, wavelength) and Reynolds stresses are used to evaluate the performance of a methodology for the incorporation of non-equilibrium ripple dynamics into the calculations of...
Floral herbivory in the carnivorous plant, Sarracenia alataNARA Subscribed
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
How climate constrains species’ distributions through time and space is an important question in the context of conservation planning for climate change. Despite increasing awareness of the need to incorporate mechanism into species distribution models ( SDM s), mechanistic modeling of endotherm distributions remains limited in this literature. Using the American pika ( Ochotona princeps ) as an example, we present a framework...
Fine mapping of 14q24.1 breast cancer susceptibility locusNARA Subscribed