Patients with peritoneal metastases (PM) of colorectal cancer have a very poor outcome. Intraperitoneal delivery of chemotherapy is the preferred route for PM treatment. The main limitation of the treatment options is the short residence time of the cytostatic, with subsequent short exposure of the cancer cells. To address this, a supramolecular hydrogel has been developed that allows both local and slow release of its encapsu...

For peritoneal metastases (PM), there are few curative treatment options, and they are only available for a select patient group. Recently, new therapies have been developed to deliver intraperitoneal chemotherapy for a prolonged period, suitable for a larger patient group. These drug delivery systems (DDSs) seem promising in the experimental setting. Many types of DDSs have been explored in a variety of animal models, using d...

Community reassembly is an important concept in community ecology, but in most circumstances cannot be observed and is hypothetical. Reassembly of communities is an observable process that can be examined effectively following species invasions. Our study system in southeastern Arizona has declined in diversity and abundance of native winter annual plants coincident with a sustained irruption of a nonnative invasive Eurasian s...