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The Current deposit is hosted by serpentinized peridotite that intruded rocks of the Quetico Subprovince in the Midcontinent Rift, and is subdivided into three morphologically distinct regions — the shallow and thin Current–Bridge Zone in the northwest, the deep and thick 437–Southeast Anomaly (SEA) Zone in the southeast, and the thick Beaver–Cloud Zone in the middle. The magma parental to the Current deposit became saturated...
Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer’s Disease Mouse ModelsNARA Subscribed
Based upon its interactions with amyloid β peptide (Aβ), the amylin receptor, a class B G protein-coupled receptor (GPCR), is a potential modulator of Alzheimer’s disease (AD) pathogenesis. However, past pharmacological approaches have failed to resolve whether activation or blockade of this receptor would have greater therapeutic benefit. To address this issue, we generated compound mice expressing a human amyloid precursor p...
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