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The fusion of therapeutic proteins to the Fc domain of monoclonal antibodies (mAbs) generally improves the proteins' pharmacokinetic (PK) characteristics, extending in vivo half-lives due to the binding of the Fc domain to the FcRn receptor. Yet, several of these Fc-fusion biologics have been observed to have unexpected rapid clearance associated with non-specific off-target binding. Variability in non-specific clearance is of...
Iron‐limitation within the California Current System drives changes in phytoplankton taxonomic composition and photo‐physiology over a range of spatial scales. Here we demonstrate how these iron‐dependent signatures can be resolved, with high spatial resolution, using continuous ship‐board optical measurements. Deck‐board incubation experiments, along with discrete measurements of iron and macro nutrient concentrations and mol...
Predicting invasiveness of freshwater fishes imported into North America: regional differences in models and outcomesNARA Subscribed
Biological invasions driven by international trade heighten the urgency for development of invasion risk models, as the traits and parameters that consistently predict successful invasion remain unresolved. For four regions of North America that include parts of the United States and Canada (Sacramento-San Joaquin River Basins, Lower Colorado River Basin, Great Lakes Region, Mid-Atlantic Region), we construct and compare class...
Language matters in shaping perceptions and guiding behaviour. The term stakeholder is widely used, yet little attention is paid to the possibility that its use may inadvertently perpetuate colonial narratives and reinforce systemic inequities. In this article, we critically examine the limitations of the stakeholder concept and its ambiguity, normativity, and exclusionary implications. We emphasise the importance of using lan...
Incidence and risk factors for respiratory tract bacterial colonization and infection in lung transplant recipientsNARA Subscribed
To evaluate incidence of and risk factors for respiratory bacterial colonization and infections within 30 days from lung transplantation (LT). We retrospectively analyzed microbiological and clinical data from 94 patients transplanted for indications other than cystic fibrosis, focusing on the occurrence of bacterial respiratory colonization or infection during 1 month of follow-up after LT. Thirty-three percent of patients de...
Purpose Capecitabine is an oral pre-pro-drug of the anti-cancer drug 5-fluorouracil (5-FU). The biological activity of the 5-FU degrading enzyme, dihydropyrimidine dehydrogenase (DPD), and the target enzyme thymidylate synthase (TS), are subject to circadian rhythmicity in healthy volunteers. The aim of this study was to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), safety, pharmacokinetics (PK) and...
TRY plant trait database – enhanced coverage and open accessNARA Subscribed
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodivers...