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Introduction Systemic inflammation and endothelial dysfunction are potentially modifiable factors implicated in Alzheimer’s disease (AD), which offer potential therapeutic targets to slow disease progression. Methods We investigated the relationship between baseline circulating levels of inflammatory (TNF-α, IL-1ß) and endothelial cell markers (VCAM-1, ICAM-1, E-selectin) and 18-month cognitive decline (ADAS-cog12) in 266 mild...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Anthropogenic inputs from a coastal megacity are linked to greenhouse gas concentrations in the surrounding estuaryNARA Subscribed
Coastal megacities deposit significant amounts of carbon (C), nitrogen (N), and pollutants into surrounding waters. In urbanized estuaries, these inputs, including wastewater discharge and surface runoff, can affect biogeochemical cycles, microbial production, and greenhouse gas (GHG) efflux. To better understand estuarine GHG production and its connection to anthropogenic drivers, we quantified carbon dioxide (CO 2 ) and meth...
Homogenization and analysis of an expanded long‐term monthly rainfall network for the Island of Ireland (1850–2010)NARA Subscribed
Long‐term precipitation series are critical for understanding emerging changes to the hydrological cycle. To this end we construct a homogenized Island of Ireland Precipitation ( IIP ) network comprising 25 stations and a composite series covering the period 1850–2010, providing the second‐longest regional precipitation archive in the British‐Irish Isles. We expand the existing catalogue of long‐term precipitation records for...
Cytonuclear disequilibrium in a hybrid zone involving deep‐sea hydrothermal vent mussels of the genus BathymodiolusNARA Subscribed
A hybrid zone involving the deep‐sea mussels, Bathymodiolus azoricus and B. puteoserpentis , was recently discovered at Broken Spur hydrothermal vent field (29°10′ N, 43°10′ W) along an intermediate segment of the Mid‐Atlantic Ridge axis. Examination of nuclear (allozymes) and cytoplasmic (mitochondrial DNA) gene markers in a new sample from Broken Spur revealed significant cytonuclear disequilibrium caused by an excess of the...
A hybrid zone between hydrothermal vent mussels (Bivalvia: Mytilidae) from the Mid‐Atlantic RidgeNARA Subscribed
This study provides the first example of a hybrid zone between animal taxa distributed along the mid‐ocean ridge system. We examined the distribution and genetic structure of deep‐sea hydrothermal vent mussels (Bivalvia: Mytilidae) along a 2888‐km portion of the Mid‐Atlantic Ridge between 37°50′ N and 14°45′ N latitude. Mitochondrial DNA (mtDNA), allozymes and multivariate–morphometric evidence discriminated between individual...
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