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Enhancing gene flow through translocations can be a useful tool in recovering small and isolated populations. However, it is not devoid of genetic risks, such as outbreeding depression in future generations, that can have negative consequences in terms of the establishment and mean fitness of the population. Studies that monitor the long-term effects of genetic rescue on populations in the wild are few, especially for snakes....
LARES-2 contribution to global geodetic parameters from the combined LAGEOS-LARES solutionsNARA Subscribed
LARES-2 is a new geodetic satellite designed for high-accuracy satellite laser ranging. The orbit altitude of LARES-2 is similar to that of LAGEOS-1, whereas the inclination angle of 70° complements the LAGEOS-1 inclination of 110°; hence, both satellites form the butterfly configuration for the verification of the Lense–Thirring effect. Although the major objective of LARES-2 is testing general relativity, LARES-2 substantial...
Mechanistic in silico explorations of the immunogenic and synergistic effects of radiotherapy and immunotherapy: a critical reviewNARA Subscribed
Immunotherapy is a rapidly evolving field, with many models attempting to describe its impact on the immune system, especially when paired with radiotherapy. Tumor response to this combination involves a complex spatiotemporal dynamic which makes either clinical or pre-clinical in vivo investigation across the resulting extensive solution space extremely difficult. In this review, several in silico models of the interaction be...
The improvement of the in vitro plant regeneration in barley with the epigenetic modifier of histone acetylation, trichostatin ANARA Subscribed
Genotype-limited plant regeneration is one of the main obstacles to the broader use of genetic transformation in barley breeding. Thus, developing new approaches that might improve responses of in vitro recalcitrant genotypes remains at the center of barley biotechnology. Here, we analyzed different barley genotypes, including “Golden Promise,” a genotype commonly used in the genetic transformation, and four malting barley cul...
Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergyNARA Subscribed
Purpose Ongoing angiogenesis renders the tumor endothelium unresponsive to inflammatory cytokines and interferes with adhesion of leukocytes, resulting in escape from immunity. This process is referred to as tumor endothelial cell anergy. We aimed to investigate whether anti-angiogenic agents can overcome endothelial cell anergy and provide pro-inflammatory conditions. Experimental design Tissues of renal cell carcinoma (RCC)...
Diagnosing similarities in probabilistic multi-model ensembles: an application to soil–plant-growth-modelingNARA Subscribed
There has been an increasing interest in using multi-model ensembles over the past decade. While it has been shown that ensembles often outperform individual models, there is still a lack of methods that guide the choice of the ensemble members. Previous studies found that model similarity is crucial for this choice. Therefore, we introduce a method that quantifies similarities between models based on so-called energy statisti...
What can cold‐induced transcriptomes of Arctic Brassicaceae tell us about the evolution of cold tolerance?NARA Subscribed
Little is known about the evolution of cold tolerance in polar plant species and how they differ from temperate relatives. To gain insight into their biology and the evolution of cold tolerance, we compared the molecular basis of cold response in three Arctic Brassicaceae species. We conducted a comparative time series experiment to examine transcriptional responses to low temperature. RNA was sampled at 22°C, and after 3, 6,...
Distance decay 2.0 – A global synthesis of taxonomic and functional turnover in ecological communitiesNARA Subscribed
Aim Understanding the variation in community composition and species abundances (i.e., β‐diversity) is at the heart of community ecology. A common approach to examine β‐diversity is to evaluate directional variation in community composition by measuring the decay in the similarity among pairs of communities along spatial or environmental distance. We provide the first global synthesis of taxonomic and functional distance decay...
Measuring and modelling microclimatic air temperature in a historically degraded tropical forestNARA Subscribed
Climate change is predicted to cause widespread disruptions to global biodiversity. Most climate models are at the macroscale, operating at a ~ 1 km resolution and predicting future temperatures at 1.5–2 m above ground level, making them unable to predict microclimates at the scale that many organisms experience temperature. We studied the effects of forest structure and vertical position on microclimatic air temperature withi...
Avian seed dispersal may be insufficient for plants to track future temperature change on tropical mountainsNARA Subscribed
Aim Climate change causes shifts in species ranges globally. Terrestrial plant species often lag behind temperature shifts, and it is unclear to what extent animal‐dispersed plants can track climate change. Here, we estimate the ability of bird‐dispersed plant species to track future temperature change on a tropical mountain. Location Tropical elevational gradient (500–3500 m.a.s.l.) in the Manú biosphere reserve, Peru. Time p...
Cleaner seas: reducing marine pollutionNARA Subscribed
Functional traits offer a rich quantitative framework for developing and testing theories in evolutionary biology, ecology and ecosystem science. However, the potential of functional traits to drive theoretical advances and refine models of global change can only be fully realised when species‐level information is complete. Here we present the AVONET dataset containing comprehensive functional trait data for all birds, includi...
Carriage of ESBL-producing Enterobacterales in wastewater treatment plant workers and surrounding residents — the AWARE StudyNARA Subscribed
To investigate whether wastewater treatment plant (WWTP) workers and residents living in close proximity to a WWTP have elevated carriage rates of ESBL-producing Enterobacterales, as compared to the general population. From 2018 to 2020, we carried out a cross-sectional study in Germany, the Netherlands, and Romania among WWTP workers (N = 344), nearby residents (living ≤ 300 m away from WWTPs; N = 431) and distant residents (...
sPlotOpen – An environmentally balanced, open‐access, global dataset of vegetation plotsNARA Subscribed
Motivation Assessing biodiversity status and trends in plant communities is critical for understanding, quantifying and predicting the effects of global change on ecosystems. Vegetation plots record the occurrence or abundance of all plant species co‐occurring within delimited local areas. This allows species absences to be inferred, information seldom provided by existing global plant datasets. Although many vegetation plots...