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Voxel-wise insights into early Alzheimer’s disease pathology progression: the association with APOE and memory declineNARA Subscribed
Longitudinal investigation of the Apolipoprotein E (APOE) genotype’s impact on Alzheimer’s disease (AD) biomarker progression, focusing on amyloid beta (Aβ) accumulation and gray matter (GM) atrophy, integrating cognitive decline and baseline levels. Longitudinal florbetapir-PET and T1-weighted MRI data from 100 cognitively normal (CN) and mild cognitive impaired (MCI) participants both with considerable global Aβ accumulation...
Purpose The purpose of the study was to explore the validity, test–retest reliability and affective responses of a submaximal 20-m shuttle-run test (20mSRT) stopped at 6 on the Eston–Parfitt (EP) scale. The secondary aim was to examine and compare two submaximal 20mSRT protocols with different RPE end points (EP6 vs. EP7) using previously published data. Methods Twenty-five children (16 boys; 13.4 ± 1.0 years; 162.1 ± 8.7 cm;...
Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia predictionNARA Subscribed
DNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging biomarkers linked to dementia risk. We investigated their relationship and combined potential for prediction of cognitive impairment and future dementia risk using the ADNI database. Of several MA algorithms, DunedinPACE and GrimAge2, associated with memory, were combined in a composite MA alongside BA and a data-driven FI in predictive analyse...
Ratings of perceived exertion from a submaximal 20-m shuttle run test predict peak oxygen uptake in children and the test feels betterNARA Subscribed
Purpose To determine the validity and test–retest reliability of using ratings of perceived exertion (RPE) elicited during a submaximal 20-m Shuttle Run Test (20mSRT) to predict VO 2peak in children and investigate acute affective responses. Methods Twenty-five children (14 boys; age, 12.8 ± 0.7 years; height, 162.0 ± 9.3 cm; mass, 49.9 ± 7.7 kg) completed four exercise tests (GXT, 2 submaximal 20mSRT, maximal 20mSRT). The Est...
Guiding principles for rewildingNARA Subscribed
There has been much recent interest in the concept of rewilding as a tool for nature conservation, but also confusion over the idea, which has limited its utility. We developed a unifying definition and 10 guiding principles for rewilding through a survey of 59 rewilding experts, a summary of key organizations’ rewilding visions, and workshops involving over 100 participants from around the world. The guiding principles convey...
Humans in the Hoxnian: habitat, context and fire use at Beeches Pit, West Stow, Suffolk, UKNARA Subscribed
A Lower Palaeolithic industry at Beeches Pit, West Stow, Suffolk, occurs within an interglacial sequence that immediately overlies glacial deposits, referable to the Anglian Lowestoft Formation. There is strong biostratigraphical evidence from both vertebrates and molluscs that the interglacial represented is the Hoxnian (MIS 11). This conclusion is supported by uranium series dates from carbonate nodules (>400 kyr), TL dates...
s 60th annual PAA meeting (Part II)NARA Subscribed
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