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Mechanisms of breast cancer dormancy in bone metastasisNARA Subscribed
Bone metastasis remains a serious threat to breast cancer patients. This condition arises from the outgrowth of previously dormant tumour cells in this site. Dormant tumour cells are almost impossible to detect in human patents, and these cells acquire “stem like” characteristics rendering them resistant to current cancer therapies. Furthermore, the development of therapies to target this population has proved challenging. The...
Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populationsNARA Subscribed
Genetic and other predisposing factors can influence the progression from initiation of drug intake to compulsive substance use through distinct biobehavioral processes. Operant cocaine self-administration studies in laboratory mice offer a powerful method to dissect the biology of this progression from initiation, dose-response, extinction, and cued reinstatement in a controlled, tractable system. However, many such studies e...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Actionable Steps to Address Disparities in Healthcare Among US Patients With Multiple Myeloma: A Patient PerspectiveNARA Subscribed
Patients with multiple myeloma (MM), patient advocates, healthcare providers (HCPs), and industry sponsors gathered at 2 MM Health Equity Summits to discuss their experiences and perspectives on MM healthcare inequities in the US. Eight topics relevant to the patient experience were identified at the first summit, prioritized by participant survey, and aligned on by the entire group. Two topics were then selected for priority...
The estimates of the sensible and latent heat fluxes are explored for two semi-arid locations using standard measurements of temperature and humidity at two levels in the surface layer. The sensible heat flux estimated with the stability functions proposed by Businger has values within the tolerable error in complex terrain, except when the surface is wet and irradiation is high. These cases correspond to a regime dominated by...
Entanglement is one of the primary anthropogenic threats to the North Atlantic right whale ( Eubalaena glacialis ; right whale) whose habitat overlaps fixed-gear fishing grounds in the Northwest Atlantic with entanglements representing around half of the mortality and serious injury incidents. Right whale mortality has reached levels that require intervention under the Marine Mammal Protection Act, creating the need for a tool...
This work, conducted within the framework of the international network CRESTE (Coastal Resilience Using Satellites), examines the role of resilience in monitoring coastal evolution across diverse environments in Europe (France, The Netherlands), America (Mexico), Asia (China), and Oceania (Australia). High-resolution morphological datasets, derived from in situ measurements and video monitoring systems, were analyzed for wave-...
Haploblocks are regions of the genome that coalesce to an ancestor as a single unit. Differentiated haplotypes in these regions can result from the accumulation of mutational differences in low‐recombination chromosomal regions, especially when selective sweeps occur within geographically structured populations. We introduce a method to identify large well‐differentiated haploblock regions (LHBRs), based on the variance in sta...