EPAA’s ‘NAM Designathon 2023’ challenge for human toxicity sought to identify a classification system capable of categorising chemicals based on their bioactivity and bioavailability properties determined using non-animal methodologies (Worth et al. 2025). The proposal is made to classify chemicals into three levels of concern: low concern could be used without restriction, medium concern requiring assessment to establish safe...

Objective Demographic changes encompass societies to maintain the work ability (WA) of aging workforces. The present study explored the relationship between modifiable lifestyle factors, cognitive functions, and their influence on WA, using a multi-group structural equation approach. Method Cross-sectional data from 247 middle-aged and 236 older employees from the Dortmund Vital Study were included in this analysis. We propose...

Changes in species diversity can be an indicator of ecosystem disturbance, impairment, or recovery. Estimating sampling effort needed to adequately represent stream fish assemblages is necessary for informing conservation actions. Increased sampling intensity can increase species detection, affecting the accuracy and precision of biodiversity indices. Seining is commonly used in fish surveys in sand-bottomed streams of the wes...