Exome sequencing (ES) has become a primary tool for diagnosing neurodevelopmental disorders (NDDs), yet the interpretation of genetic variants in large, heterogeneous cohorts presents significant challenges that automated pipelines often fail to resolve. This study showcases the complexities and novel findings derived from a decade-long analysis of 419 Italian NDD patient-parent trios. While ES established a molecular diagnosi...

The transition period is an extremely critical phase for the Mediterranean lactating buffaloes, characterized by a state of oxidative stress. Oral administration of antioxidants is common. However, the aim of this study was to evaluate whether the intramuscular administration of a vitamin combination, containing α-tocopherol and β-carotene, could improve both milk quality and reproductive performance. The animals were divided...

Olive mill wastewaters (OMWWs) present a substantial environmental challenge due to their high organic content. This study investigates sustainable OMWW management, focusing on field application, using a GIS-based approach to identify suitable areas in Sicily, Italy. Integrating regulatory, agronomic, hydropedological, and economic factors, the research offers a comprehensive evaluation of OMWW disposal strategies by explicitl...

A molecular tool has been developed for the molecular identification of Ips sexdentatus (Börner 1776) (Coleoptera Curculionidae Scolytidae), the well-known six thooted bark beetle, widely distributed in Eurasia, where it infests several species of the genus Pinus and occasionally a few conifer species of the genera Abies , Larix and Picea . The developed test can be useful both in countries where I. sexdentatus is handled as a...

In older populations, sensitive fall risk assessment tools are important to timely intervene and prevent falls. Instrumented assessments have shown to be superior to standardized fall risk assessments such as the Timed Up and Go Test (TUG) and should capture both motor and cognitive functions. Therefore, the aim was to test novel instrumented assessments with and without a cognitive component. One hundred thirty-seven older ad...

Assessment of flood damage caused by dam failures is typically performed deterministically on the basis of a single preselected scenario, neglecting uncertainties in dam-break parameters, exposure information, and vulnerability model. This paper proposes a probabilistic flood damage model for the estimation of life loss due to dam-break flooding with the aim of overcoming this limitation and performing a more comprehensive and...