D. Rose results 297
· Newest (Page 1/12, per page 25)
Author: D. Rose ×Clear All Filters
Search Results
Identification of a novel isoform of Slc26a4 by single-cell RNA-sequencing of pendrin-expressing cells in the cochleaNARA Subscribed
Pathogenic variation of SLC26A 4 gene causes both Pendred syndrome (PDS) and non-syndromic enlarged vestibular aqueduct (NSEVA/DFNB4), two autosomal recessive disorders. The former accounts for approximately 6% of human genetic hearing loss, making it the second most common form of syndromic deafness after Usher syndrome, while the latter is the most common radiological malformation associated with childhood sensorineural hear...
The high-value tropical sea cucumber Holothuria ( Metriatyla ) scabra or sandfish is central to the ‘400+ year old global’, bêche-de-mer trade. Consequently, it has faced heavy exploitation and has become extirpated in some regions within its broader Indo-Pacific natural distribution. Recent molecular evidence has provided clarity on its taxonomic identity, indicating it comprises a species complex, with four broad lineages de...
Despite growing scientific evidence of the important role that wood-decomposing fungi serve in ecosystem function, we know little about how fungal community dynamics relate to decomposition outcomes. We deployed 42 standardized (same dimensions and source) wood stakes from sugar maple ( Acer saccharum ) and white ash ( Fraxinus americana ) on the forest floor of a northern US hardwood forest. After four years, we collected the...
The Effects of Ocean Warming and Acidification on Fatty Acid Contents of Marine Organisms: A Global Meta‐AnalysisNARA Subscribed
Ocean warming and acidification pose significant threats to marine biodiversity and human nutrition by fundamentally altering the biochemical composition of marine organisms. A primary concern is the potential decline in omega‐3 fatty acids (FAs) that are essential to human health and primarily obtained through seafood consumption. The influence of these climate stressors on FA content across marine food webs remains poorly un...
Testosterone (T) and dehydroepiandrosterone sulfate (DHEAS) are two steroids integral to male primate development. For humans, both are high in early infancy (for T, this is known as minipuberty) then rapidly decline. DHEAS then increases beginning in early childhood, resulting in a process known as adrenarche, which signals the maturation of the zona reticularis of the adrenal gland. T increases a few years thereafter, markin...
Bottom‐tow gear fisheries (trawls and dredges) produce ~24 million mt of harvest annually, representing a globally important animal‐sourced food system. While many are currently sustainably managed, growing concern over the potential for ecosystem impacts from bottom‐tow gears has increased pressure to improve these fisheries. We assembled an international working group of > 30 contributors, including fishing industry particip...
Micro-computed tomography of the unique skeleton of Eurotamandua joresi Storch, 1981 (middle Eocene, Grube Messel)—initially described as the oldest myrmecophagid and the only known Old World xenarthran—reveals details of its skeletal anatomy that were previously obscured, enabling close comparative study for the first time. In this report we focus on the forelimb. The segmentation of scapula, humerus, radius, ulna, carpals, m...
Northeast Pacific (NEP) blue whales are one of the world’s most accessible and well-studied populations of blue whales. They are specialist krill feeders and have historically been described as capital breeders that feed off Southern California in the summer and breed in the Eastern Tropical Pacific in the winter. Recent studies have challenged this stereotypical characterization by describing large variations in NEP blue whal...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Adapting Species Risk Assessments to a Changing Climate: The Underestimated Vulnerability of Foundational TreesNARA Subscribed
Climate change is one of the top threats to biodiversity. However, many species risk assessment frameworks, including the globally authoritative International Union for Conservation of Nature Red List, do not consistently and comprehensively incorporate loss of climatically suitable habitat into listing or threat categorization decisions. Using California's foundational, endemic and near‐endemic trees as an exemplary set of hi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...