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Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Aim Aims of the study are to examine patterns of range‐wide genetic differentiation and population structure in a headwater obligate salamander living in a geologically rich region, to identify genetically distinct populations and areas of gene flow between them. Location Oregon and Washington in the Pacific Northwest, United States of America. Time Period Tissue samples were collected in 2022 and 2023. Major Taxa Studied The...
Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor developmentNARA Subscribed
Organismal aging has been associated with diverse metabolic and functional changes across tissues. Within the immune system, key features of physiological hematopoietic cell aging include increased fat deposition in the bone marrow, impaired hematopoietic stem and progenitor cell (HSPC) function, and a propensity towards myeloid differentiation. This shift in lineage bias can lead to pre-malignant bone marrow conditions such a...
Hexanucleotide repeat expansions (HREs) in the chromosome 9 open reading frame 72 ( C9orf72 ) gene are the most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both are debilitating neurodegenerative conditions affecting either motor neurons (ALS) in the brain and spinal cord or neurons in the frontal and/or temporal cortical lobes (FTD). HREs undergo repeat-associated non-ATG (...
Wind and small mammals are complementary fungal dispersersNARA Subscribed
Following a disturbance, dispersal shapes community composition as well as ecosystem structure and function. For fungi, dispersal is often wind or mammal facilitated, but it is unclear whether these pathways are complementary or redundant in the taxa they disperse and the ecosystem functions they provide. Here, we compare the diversity and morphology of fungi dispersed by wind and three rodent species in recently harvested for...
Book reviewNARA Subscribed