The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. Precision geromedicine represents a paradigm shift in targeting the biological processes of ageing to optimise health and healthspan, which likely requires multimodal tailored interventions. PROMETHEUS, as part of the XPRIZE healthspan semi-finalist competition, is an 8-week feasibility and exploratory study including 20 m...

Down syndrome (DS), or trisomy 21 (T21), represents the most common genetic cause of intellectual disability worldwide and is associated with a wide range of medical, developmental, and neurodegenerative conditions, including a universal predisposition to early-onset Alzheimer’s disease (AD). Since its establishment in 2014, the Trisomy 21 Research Society (T21RS) has provided a global forum for advancing DS research across di...

The Amundsen Sea polynya hosts intense sea ice formation, but, due to the presence of relatively warm and salty modified Circumpolar Deep Water, the cold, brine-enriched water is not typically dense enough to sink to the deep ocean. A hydrographic survey of the Dotson Ice Shelf region in the Amundsen Sea using two ocean gliders identified and characterised subsurface lenses containing water with temperatures less than −1.70 °C...

Key message Superoxide accumulates during early stigma papillae growth stages in Arabidopsis. Abstract Highly specialized stigma papillae cells play a critical role in plant reproduction. Their main purpose is to catch and interact with pollen, to mediate compatibility responses, to regulate pollen germination, and to guide pollen tubes to the transmitting tract so that the sperm cells carried in the pollen can be delivered to...

Climate change is altering precipitation regimes that control nitrogen (N) cycling in terrestrial ecosystems. In ecosystems exposed to frequent drought, N can accumulate in soils as they dry, stimulating the emission of both nitric oxide (NO; an air pollutant at high concentrations) and nitrous oxide (N 2 O; a powerful greenhouse gas) when the dry soils wet up. Because changes in both N availability and soil moisture can alter...

Along U.S. Atlantic and Gulf Coast barrier islands, red foxes ( Vulpes vulpes ) are top predators that are thought to impact smaller mesopredators and depredate beach-nesting birds. Starting in 2015, sarcoptic mange epizootics among red foxes led to their eventual temporary extirpation from most of Fire Island, NY, USA. We monitored the subsequent changes to the mammalian predator community on this barrier island and explored...

The Australian lungfish, Neoceratodus forsteri, is one of the world’s oldest vertebrate lineages, with a slow life-history and threatened status, requiring immediate conservation efforts. The main threats to lungfish populations are degradation and availability of key macrophyte habitats, water regulation and flow modification. As this long-lived species (at least 77 years) has delayed maturity (mature at 10 years), field moni...