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Measurable residual disease testing in acute myeloid leukemia: current state, foundational models, and tools for future developmentNARA Subscribed
Acute myeloid leukemia (AML) is a lethal and rapidly progressive hematologic malignancy with high rates of relapse and treatment refractoriness. Management of AML is complicated by biological heterogeneity in a disease that is broadly defined by the clonal expansion of myeloblasts that otherwise play an important role in healthy marrow tissues. While subtypes of AML are increasingly defined by druggable driver mutations includ...
The genetic architecture of temperature-induced partial fertility restoration in A1 cytoplasm in sorghum (Sorghum bicolor (L.) Moench)NARA Subscribed
Key message High-temperature-induced partial fertility in CMS sorghum is controlled by multiple genes that are distinct from genes involved in fertility restoration, contributing to reduced diversity in elite females. Abstract Cytoplasmic male sterility (CMS) is used for commercial production of hybrid seed in sorghum. CMS-based hybrid breeding systems require female parental lines (CMS lines) to remain male sterile to prevent...
Defining an ageing-related pathology, disease or syndrome: International Consensus StatementNARA Subscribed
Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndrom...
Effects of grid spacing on high-frequency precipitation variance in coupled high-resolution global ocean–atmosphere modelsNARA Subscribed
High-frequency precipitation variance is calculated in 12 different free-running (non-data-assimilative) coupled high resolution atmosphere–ocean model simulations, an assimilative coupled atmosphere–ocean weather forecast model, and an assimilative reanalysis. The results are compared with results from satellite estimates of precipitation and rain gauge observations. An analysis of irregular sub-daily fluctuations, which was...
Exploring controls of the early and stepped deglaciation on the western margin of the British Irish Ice SheetNARA Subscribed
New optically stimulated luminescence dating and Bayesian models integrating all legacy and BRITICE‐CHRONO geochronology facilitated exploration of the controls on the deglaciation of two former sectors of the British–Irish Ice Sheet, the Donegal Bay (DBIS) and Malin Sea ice‐streams (MSIS). Shelf‐edge glaciation occurred ~27 ka, before the global Last Glacial Maximum, and shelf‐wide retreat began 26–26.5 ka at a rate of ~18.7–...
Predicting the future response of ice sheets to climate warming and rising global sea level is important but difficult. This is especially so when fast‐flowing glaciers or ice streams , buffered by ice shelves, are grounded on beds below sea level. What happens when these ice shelves are removed? And how do the ice stream and the surrounding ice sheet respond to the abruptly altered boundary conditions? To address these questi...
Maximum extent and readvance dynamics of the Irish Sea Ice Stream and Irish Sea Glacier since the Last Glacial MaximumNARA Subscribed
The BRITICE‐CHRONO Project has generated a suite of recently published radiocarbon ages from deglacial sequences offshore in the Celtic and Irish seas and terrestrial cosmogenic nuclide and optically stimulated luminescence ages from adjacent onshore sites. All published data are integrated here with new geochronological data from Wales in a revised Bayesian analysis that enables reconstruction of ice retreat dynamics across t...
Palaeo‐ice sheets are important analogues for understanding contemporary ice sheets, offering a record of ice sheet behaviour that spans millennia. There are two main approaches to reconstructing palaeo‐ice sheets. Empirical reconstructions use the available glacial geological and chronological evidence to estimate ice sheet extent and dynamics but lack direct consideration of ice physics. In contrast, numerically modelled sim...
Pattern, style and timing of British–Irish Ice Sheet retreat: Shetland and northern North Sea sectorNARA Subscribed
The offshore sector around Shetland remains one of the least well‐studied parts of the former British–Irish Ice Sheet with several long‐standing scientific issues unresolved. These key issues include (i) the dominance of a locally sourced ‘Shetland ice cap’ vs an invasive Fennoscandian Ice Sheet; (ii) the flow configuration and style of glaciation at the Last Glacial Maximum (i.e. terrestrial vs marine glaciation); (iii) the n...
Effects of 5-HT2C, 5-HT1A receptor challenges and modafinil on the initiation and persistence of gambling behavioursNARA Subscribed
Rationale Problematic patterns of gambling are characterised by loss of control and persistent gambling often to recover losses. However, little is known about the mechanisms that mediate initial choices to begin gambling and then continue to gamble in the face of losing outcomes. Objectives These experiments first assessed gambling and loss-chasing performance under different win/lose probabilities in C57Bl/6 mice, and then i...
Genetic composition and conservation status of coastal cutthroat trout (Oncorhynchus clarki clarki) in the San Juan Islands, WashingtonNARA Subscribed
Understanding the conservation status of native fish populations is increasingly important because they are put at risk by mounting anthropogenic pressures, including climate change. Conventional approaches to assess fish populations can be logistically challenging and cost-prohibitive. As a result, resource managers often make assumptions about the status of fish populations based on limited information. The watersheds of Was...
During the Last Glacial Maximum, Donegal in north‐west Ireland functioned as an independent centre of ice dispersal that separated and fed into the Donegal Bay Ice Lobe (sourced in the Irish Midlands) to the south and the Hebrides/Malin Sea Ice Stream to the north. We report geochronological data that demonstrate marked contrasts in the timing and rate of deglaciation in northern and southern Donegal. In northern Donegal, whic...
We present a new chronology to constrain ice‐margin retreat in the northern Irish Sea Basin. Estimates on the timing of ice thinning derived from surface exposure ages for boulders from the summits of the Isle of Man and south‐west Cumbria suggest that ice thinning was commensurate with the rapid retreat that followed the short‐lived advance of the Irish Sea Ice Stream (ISIS) to maximum limits in the Celtic Sea. This ice retre...
Animals can be important in modulating ecosystem‐level nutrient cycling, although their importance varies greatly among species and ecosystems. Nutrient cycling rates of individual animals represent valuable data for testing the predictions of important frameworks such as the Metabolic Theory of Ecology ( MTE ) and ecological stoichiometry ( ES ). They also represent an important set of functional traits that may reflect both...
New age constraints for the limit of the British–Irish Ice Sheet on the Isles of ScillyNARA Subscribed
The southernmost terrestrial extent of the Irish Sea Ice Stream (ISIS), which drained a large proportion of the last British–Irish Ice Sheet, impinged on to the Isles of Scilly during Marine Isotope Stage 2. However, the age of this ice limit has been contested and the interpretation that this occurred during the Last Glacial Maximum (LGM) remains controversial. This study reports new ages using optically stimulated luminescen...