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NARA Subscribed1
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Springer Nature1
Journal
Cell and Tissue Research1
Publication Year
20211
D. Thenet results 1 · Newest (Page 1/1, per page 25)
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Author: D. Thenet ×Clear All Filters
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Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathyNARA Subscribed
Cell and Tissue Research · 2021 · Vol. 386 · Issue 1 · Springer
K. E. Ng; P. J. Delaney; D. Thenet; S. Murtough; C. M. Webb; N. Zaman; E. Tsisanova; G. Mastroianni; S. L. M. Walker; J. D. Westaby; D. J. Pennington; R. Pink; D. P. Kelsell; A. Tinker
The study of a desmoglein 2 murine model of arrhythmogenic cardiomyopathy revealed cardiac inflammation as a key early event leading to fibrosis. Arrhythmogenic cardiomyopathy (AC) is an inherited heart muscle disorder leading to ventricular arrhythmias and heart failure due to abnormalities in the cardiac desmosome. We examined how loss of desmoglein 2 ( Dsg2 ) in the young murine heart leads to development of AC. Apoptosis w...
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