D. Volpi results 22
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Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscleNARA Subscribed
Sarcopenia increases the risk of frailty, morbidity, and mortality in older adults. Resistance exercise training improves muscle size and function; however, the response to exercise training is variable in older adults. The objective of our study was to determine both the age-independent and age-dependent changes to the transcriptome following progressive resistance exercise training. Skeletal muscle biopsies were obtained bef...
The archipelago of the Aeolian Islands in the Tyrrhenian Sea is a globally important natural laboratory. The archipelago, declared a UNESCO World Heritage Site for its unique geology and biodiversity, offers a unique opportunity to study plastic pollution. This study presents an initiative to assess the occurrence of plastic pellets on the beaches of five Aeolian Islands. It provides an insight into the polymer composition and...
NEOTROPICAL FRESHWATER FISHES : A dataset of occurrence and abundance of freshwater fishes in the NeotropicsNARA Subscribed
The Neotropical region hosts 4225 freshwater fish species, ranking first among the world's most diverse regions for freshwater fishes. Our NEOTROPICAL FRESHWATER FISHES data set is the first to produce a large‐scale Neotropical freshwater fish inventory, covering the entire Neotropical region from Mexico and the Caribbean in the north to the southern limits in Argentina, Paraguay, Chile, and Uruguay. We compiled 185,787 distri...
Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapyNARA Subscribed
Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS). This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids. Since 2006, enzyme replacement therapy (ERT) has been clinically applied, showing eff...
Charcot-Marie-Tooth disease type 1A (CMT1A), caused by duplication of the peripheral myelin protein 22 ( PMP22 ) gene, and CMT1B, caused by mutations in myelin protein zero ( MPZ ) gene, are the two most common forms of demyelinating CMT (CMT1), and no treatments are available for either. Prior studies of the Mpz Ser63del mouse model of CMT1B have demonstrated that protein misfolding, endoplasmic reticulum (ER) retention and a...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Seismic hazard for the Trans Adriatic Pipeline (TAP). Part 2: broadband scenarios at the Fier Compressor Station (Albania)NARA Subscribed
To ensure environmental and public safety, critical facilities require rigorous seismic hazard analysis to define seismic input for their design. We consider the case of the Trans Adriatic Pipeline (TAP), which is a pipeline that transports natural gas from the Caspian Sea to southern Italy, crossing active faults and areas characterized by high seismicity levels. For this pipeline, we develop a Probabilistic Seismic Hazard As...
Seismic hazard for the Trans Adriatic Pipeline (TAP). Part 1: probabilistic seismic hazard analysis along the pipelineNARA Subscribed
The design of critical facilities needs a targeted computation of the expected ground motion levels. The Trans Adriatic Pipeline (TAP) is the pipeline that transports natural gas from the Greek-Turkish border, through Greece and Albania, to Italy. We present here the probabilistic seismic hazard analysis (PSHA) that we performed for this facility, and the deaggregation of the results, aiming to identify the dominant seismic so...
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