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Prioritizing clinical utility to use allostatic load as a biomarker of the consequences of stressNARA Subscribed
Allostatic load measures the physiological consequences of stress and is associated with disease outcomes. Clinical use of allostatic load is limited, in part, because its calculation requires biomarkers not routinely measured in clinical care. Presently, we evaluated associations between high allostatic load and depression as co-occurring consequences of stress among a cohort representing population subgroups largely excluded...
Assessing Climate Adaptation Among Canada Lynx ( Lynx canadensis ) Populations at the Trailing EdgeNARA Subscribed
Species must acclimate, shift their distribution, or adapt in place in response to anthropogenic climate change. Populations at the low‐latitude trailing edge of the species distribution typically experience thermal conditions closest to the upper limit of their thermoregulatory capacity. Landscape and functional genomic approaches provide quantitative measures of risk and adaptive capacity which can inform and prioritise cons...
Since its consolidation as a sub‐discipline of ecology in the late 1990s, urban ecology has grown substantially, enhancing our understanding of how urbanization shapes biodiversity and how biodiversity adapts to urbanization. Inherently interdisciplinary in its scope and application, urban ecology is rooted in multiple theoretical and methodological foundations, potentially making the field overwhelming for newcomers as the ke...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Planktonic response to pulse or continuous inorganic nutrient inputs: temporal variations and monitoring implicationsNARA Subscribed
Coastal lagoons are dynamic systems where the mode of nutrient input, continuous or pulsed, or a combination, can significantly affect plankton community structure and function. We conducted a spring field microcosm experiment in a Mediterranean lagoon to evaluate how three nutrient delivery regimes influence planktonic dynamics, using biomass measurements and extracellular enzyme activity (EEA) as functional indicators. Conti...
Freshwaters face increasing pressures from chemical, hydrological and climatic changes, yet tools for assessing their condition remain limited. River biofilms, composed of diverse microbial communities, integrate environmental signals over space and time, making them sensitive indicators of river health. Using 16S rRNA gene sequencing of more than 1600 biofilms collected across a national river network, we quantified bacterial...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Effects of insect herbivory on phytoestrogen concentrations in three Trifolium speciesNARA Subscribed
Phytoestrogens are plant-produced secondary compounds believed to play a protective role against environmental stress. When consumed by animals, phytoestrogens can influence animal health and reproductive function; hence, there is interest in identifying factors that trigger their production in agricultural crops. We conducted two experiments to determine if leaf tissue herbivory by corn earworm ( Helicoverpa zea Boddie) induc...
Crown Exposure Regulates Aboveground Wood Productivity Responses to Soil Fertility in Lowland Tropical ForestsNARA Subscribed
Understanding the drivers of aboveground wood productivity (AWP) in tropical forests is crucial for explaining ecosystem functioning and predicting their responses to environmental change. While climatic water availability is a well‐established driver, the role of soil nutrients and their interaction with other resources remains uncertain. We investigated how soil nutrients and light interactions shape AWP in lowland tropical...
Mosquito sex determination: recent advances and applicationsNARA Subscribed
Inorganic nutrient input effects and severity of disturbance in zooplankton community structureNARA Subscribed
Mediterranean coastal lagoons are increasingly affected by nutrient enrichment from both natural and anthropogenic sources. While most studies focus on total nutrient loads, little is known about how the mode of nutrient delivery, pulsed or continuous, affects plankton community dynamics. This study aimed to experimentally test how different nutrient input regimes influence zooplankton community structure and plankton biomass...
Activating transcription factor 4 (ATF4) is a transcription factor that mediates the response to stress at the cellular, tissue, and organism level. We deleted the gene encoding ATF4 in the proximal tubules of the mouse kidney by using a temporal and cell type-specific approach. We show that ATF4 plays a major role in regulating the transcriptome and proteome, which, in turn, influences the metabolome and kidney functions. Gen...