Ageing is a fundamental biological process marked by declining physiological function and the accumulation of stress-induced damage. It contributes to chronic disease and drives widespread alterations across organ systems, including the vasculature. Ageing of the macro- and microvasculature impairs nutrient delivery, promotes tissue degeneration, and reduces repair capacity in many tissues, including those of the musculoskelet...

Effective conservation practice requires decisions based on reliable and relevant evidence, but significant gaps in the evidence base exist. Incorporating well‐designed tests of the effectiveness of interventions for biodiversity in conservation projects is one of the best ways to scale up the rate of evidence generation. Funders of conservation projects are uniquely positioned to support and incentivize such tests as part of...

Only one last interglacial relative sea‐level indicator point (SLIP) has been recognised for Fenland, eastern England, and the nearest penultimate interglacial SLIP is located on the north Norfolk coast. Such limited information restricts the regional input to, and hence the relevance of, global reconstructions of late Middle and Late Pleistocene sea level. Marine‐influenced deposits without such relevant data are known in Fen...

The motor learning theory anticipates that cerebro-cerebellar loops perform sensorimotor prediction, thereby regulating motor control during action execution (AE) and observation (AO), but the causal interaction between the cerebellum and cerebral cortex remains unclear. Therefore, our aim was to understand what triggers neuronal activity between brain areas engaged in a visuo-motor task that involves cortico-cerebellar intera...

Purpose The purpose of this study was to assess the association between race/ethnicity and all-cause mortality among women with advanced-stage ovarian cancer who received systemic therapy. Methods We analyzed data from the National Cancer Database on women diagnosed with advanced-stage ovarian cancer from 2004 to 2015 who received systemic therapy. Race/ethnicity was categorized as Non-Hispanic (NH) White, NH-Black, Hispanic,...

Purpose Assessing factors associated with being up-to-date with colorectal cancer (CRC) screening is important for identifying populations for which targeted interventions may be needed. Methods This study used Medicare and private insurance claims data for residents of North Carolina to identify up-to-date status in the 10th year of continuous enrollment in the claims data and in available subsequent years. USPSTF guidelines...

Purpose To assess preferences for design of a pharmacy-based colorectal cancer (CRC) screening program (PharmFIT™) among screening-eligible adults in the United States (US) and explore the impact of rurality on pharmacy use patterns (e.g., pharmacy type, prescription pick-up preference, service quality rating). Methods We conducted a national online survey of non-institutionalized US adults through panels managed by Qualtrics,...