D.M. Scott results 654
· Newest (Page 1/27, per page 25)
Author: D.M. Scott ×Clear All Filters
Search Results
Deviations from additivity in APOE4-mediated late-onset Alzheimer’s disease risk across races and ethnicitiesNARA Subscribed
APOE ’s ε4 haplotype ( APOE4 ) is late onset Alzheimer’s disease’s (LOAD) strongest genetic risk factor. Therefore, accurately modeling APOE4 ’s effect is critical to understanding LOAD. This is especially important as APOE4 odds ratios (OR) vary across racial and ethnic (R/E) groups. We analyzed the APOE4 -LOAD association in 3,196 East Asian, 31,105 non-Hispanic White (White), 1,646 Hispanic and Latino (Hispanic), and 6,068...
Associations between patterns of brain connectivity and brain structural features have transdiagnostic relevance to psychopathology. There is considerable evidence for disruptions to the hippocampus and temporoparietal brain systems in psychotic disorders. The present study examines structure–function relationships—specifically, the relation of hippocampal volume with patterns of temporoparietal effective connectivity—in youth...
Nutrient Enrichment Increases Grassland Biomass Sensitivity to Interannual Precipitation VariationNARA Subscribed
Primary production underpins much of ecosystem functioning and is often limited by nutrient and water availability. Ongoing global increases in nutrient inputs and interannual precipitation variability are thus likely to impact primary production, with unclear consequences for interannual variability in plant biomass. We used data from 35 grasslands in the Nutrient Network coordinated fertilization experiment to test if nutrie...
Purpose The DANFLU-1 trial suggested lower incidence of hospitalizations for pneumonia and influenza, respiratory disease and all-cause mortality among older adults receiving high-dose (HD-IV) versus standard-dose (SD-IV) influenza vaccine. This study assessed the relative effectiveness of HD-IV versus SD-IV according to comorbidity in elderly individuals. Methods This was a post-hoc analysis of the DANFLU-1 randomized control...
Population Genomics of a Cosmopolitan Weed Provides Insights Into Its Local Adaptation and Recent Demographic HistoryNARA Subscribed
Invasive plant species present a growing ecological and economic challenge, and often adapt rapidly to their novel environments through complex demographic and evolutionary processes. Invasion genomics offers powerful tools to disentangle these processes, but most studies rely on geographically narrow sampling across native and non‐native ranges. Erigeron canadensis is a cosmopolitan weed native to North America that has succe...
Ecosystem metabolism (e.g., gross primary production [GPP], respiration [R], and net ecosystem production) integrates the activity of aerobic organisms and is an indicator of environmental change. Microplastics (i.e., particles 1–5 mm) are widespread in freshwater ecosystems and are colonized by biofilms and other organisms. However, microplastics' effects on ecosystem‐level processes including metabolism or other gas fluxes i...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Case Study of Postharvest Quality of Clearwater Russet Potato Cultivar from Commercial Production in the Columbia BasinNARA Subscribed
Potato quality traits, particularly carbohydrate composition, are shaped by genotype, management, and environment. Clearwater Russet was bred for high U.S. No. 1 yield and resistance to cold sweetening, although anecdotal reports indicate postharvest fry color varies across environments and practices. To assess this variability, five commercial fields in Washington’s Columbia Basin, spanning up to 240 km and representing diffe...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Fecal pellet packaging enhances marine carbon sequestrationNARA Subscribed
Fecal pellets produced by marine zooplankton contribute substantially to transporting biologically fixed carbon from the sunlit sea surface into deeper water layers. Their occurrence and composition are often heterogeneous, and pellets may undergo various changes while sinking, making it difficult to quantitatively assess their mechanisms of production and transformation or determine their contribution to carbon flux. To addre...