D.R. Kelly results 188
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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Local and Landscape‐Level Environmental Conditions Drive Habitat Selection Across Terrestrial Mammal SpeciesNARA Subscribed
Aim Animal movements are a fundamental process affecting communities and ecosystems. Quantifying habitat selection across species and habitats is key for understanding how animals respond to environmental change. Currently, we lack comparative studies that examine how habitat selection varies across species traits and landscapes. We aim to quantify global patterns of habitat selection to help understand the fundamental drivers...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Range-wide genetic erosion signal and deep population divergence in the declining mud shrimp Upogebia pugettensisNARA Subscribed
The Blue Mud Shrimp, Upogebia pugettensis , is an ecosystem engineer of western North American estuaries and strongly influences estuarine biogeochemical cycling, surface area, biodiversity, and trophic dynamics. In recent decades, U. pugettensis populations have declined or been extirpated over the species’ range due to infestations by the introduced Asian isopod parasite Orthione griffenis . These widespread losses highlight...
Evidence for a fisher‐designed solution to manta and devil ray bycatch in tuna fisheriesNARA Subscribed
Bycatch in global tropical tuna purse seine fisheries represents a significant source of mortality for manta and devil rays (mobulids), which are globally threatened. Use of best handling and rapid release practices on purse seine vessels can substantially reduce mortality and improve vulnerability status for mobulids. However, interventions must be effective, operationally feasible, and safe for human operators if they are to...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Sexual selection due to mate preference for certain traits can maintain phenotypic diversity within populations and species. In taxa with discrete phenotypes, such as color polymorphic species, assortative mating may lead to disruptive selection and sympatric divergence, yet how such interactions vary over species' ranges remains poorly understood. To address this shortcoming, we examined spatial patterns of sexual size dimorp...
Terrigenous inputs link nutrient dynamics to microbial communities in a tropical lagoonNARA Subscribed
Nutrient availability drives community structure and ecosystem processes, especially in tropical lagoons that are typically oligotrophic but often receive allochthonous inputs from land. Terrestrially derived nutrients are introduced to tropical lagoons by surface runoff and submarine groundwater discharge, which are influenced by seasonal precipitation. However, terrigenous inputs presumably diminish along the onshore–offshor...
Marine organisms rely on stable seawater conditions and vary in taxa-specific tolerances to environmental change. The capacity for acclimatization in marine taxa is dependent on local adaptation. Our ability to generate accurate global predictions starts in identifying regional responses, informing facets that fit globally in a mosaic of response to environmental extremes. The northwestern Gulf of Mexico (nwGoM) has not previo...
Heterotrophy of particulate organic matter subsidies contributes to divergent bleaching responses in tropical Scleractinian coralsNARA Subscribed
Heterotrophic feeding on plankton and particulate organic matter (POM) by tropical Scleractinian corals is known to aid in the resistance and recovery from thermally induced bleaching. However, the relative importance of heterotrophy in promoting bleaching resistance and recovery is likely to vary based on ecological context and the severity of heat stress. In 2019, the Pacific Island of Mo'orea experienced mass coral mortalit...
Characterization of adult hippocampal neurogenesis in adult and aged genetically diverse miceNARA Subscribed
Adult hippocampal neurogenesis—the generation of new neurons in the adult brain—declines with age, contributing to cognitive deficits in aging. While the majority of mammalian studies on neurogenesis have utilized inbred mouse strains, these models do not fully capture the genetic diversity of humans, limiting the translational relevance of their findings. The Diversity Outbred (DO) mouse model, a genetically heterogeneous pop...
Stony coral tissue loss disease (SCTLD) has spread throughout Florida’s Coral Reef, causing extensive mortality of over 30 species of reef-building corals, and has rapidly spread to many other countries and territories throughout the Caribbean. Current treatments for SCTLD, including a proprietary paste mixed with the antibiotic amoxicillin, do not provide protection from future infections and may select for antibiotic-resista...
Aim Migratory birds are under threat by climate change. Successfully conserving them requires knowing which climatic factors drive changes in their migratory behaviour. Weather conditions may directly or indirectly affect the temporally disjointed life history stages of migratory birds, including the breeding, roosting and nonbreeding stages. However, the influences of these broad‐scale patterns are often not studied together....