DAVID A. BENNETT results 91
· Newest (Page 1/4, per page 25)
Author: DAVID A. BENNETT ×Clear All Filters
Search Results
High‐Throughput Sequencing in Aquaculture Disease Investigations: Challenges and Opportunities for ImplementationNARA Subscribed
The current generation of sequencing technologies can produce terabases of data with exceptional accuracy and speed, at a fraction of the cost of older methods. Despite this unprecedented power, adoption into aquaculture health management presents several challenges, including identifying where such capability may be optimally deployed. Here we synthesise discussions from a structured expert workshop held at the 2025 Aotearoa...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Metabolic cost of external work: a novel CPET parameter optimises characterisation of exercise performance in obese individualsNARA Subscribed
Purpose Both obesity and cardiorespiratory fitness are crucial determinants of symptoms and prognosis. However, interpreting the gold-standard cardiopulmonary exercise test (CPET) is complicated by increasing body size and varying body composition. We hypothesised that the ‘metabolic cost of external work’ (or oxygen uptake (ml/min)/workload (Watts); V̇O 2 /W), a body weight-independent determinant of endurance capacity, would...
Molecular taxonomy of the guitarfish genus Acroteriobatus (Rhinopristiformes: Rhinobatidae)NARA Subscribed
Guitarfish species (genus Acroteriobatus ) display restricted distributions in undermanaged regions of intense fishing pressure. The importance of accurate specimen identification is well established, especially in the context of conservation management. However, guitarfishes remain poorly understood, which is exacerbated by taxonomic uncertainty due to morphological similarity. We therefore aimed (1) to identify molecular ope...
Supine-dependent OSA is a well-recognised OSA phenotype and may relate to craniofacial structure. Our aim was to assess whether craniofacial photos are able to identify positional OSA, specifically supine-isolated OSA, in comparison to non-positional OSA. Frontal and profile craniofacial photographs of participants were acquired according to a standardised protocol. Photographs were analysed and compared between non-positional...
Epistatic effects of IGHG and FCGRIIB genes on the development of Alzheimer’s disease in African AmericansNARA Subscribed
Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified a large number of susceptibility genes, but most of AD heritability remains unexplained, implying the existence of additional genes. Furthermore, the majority of the GWAS have been conducted in people of European descent, and the genes important for AD susceptibility in people of African descent have been underexplored. In this hypothesis-genera...
Anopheles mosquitoes are major malaria vectors, encompassing several species complexes with diverse life histories, transmission risks and insecticide resistance profiles that challenge malaria control efforts. This study investigated the genetic structure and insecticide resistance profiles of Anopheles gambiae complex mosquitoes in Tanzania. We analysed whole‐genome sequence data of 300 mosquitoes collected between 2012 and...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Motivation Pollinators play a crucial role in maintaining Earth's terrestrial biodiversity. However, rapid human‐induced environmental changes are compromising the long‐term persistence of plant‐pollinator interactions. Unfortunately, we lack robust, generalisable data capturing how plant‐pollinator communities are structured across space and time. Here, we present the EuPPollNet (European Plant‐Pollinator Networks) database,...
Challenges in assessing the effects of environmental governance systems on conservation outcomesNARA Subscribed
Effective governance is crucial for the success of conservation projects aimed at protecting wildlife populations and supporting human well‐being. However, few large‐scale, comprehensive syntheses have been conducted on the effects of different environmental governance types on conservation outcomes (i.e., biological and ecological effectiveness or effects of conservation on human well‐being), and clarity on the quantity and q...
Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α‐diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e., γ‐diversity), either due to reduced β‐diversity amplifying diversity loss or increased β‐diversity dampening diversity loss. Additionally, studies often focus on taxo...
The Kelp Forest Challenge: A collaborative global movement to protect and restore 4 million hectares of kelp forestsNARA Subscribed
Marine kelp forests cover 1/3 of our world's coastlines, are heralded as a nature-based solution to address socio-environmental issues, connect hundreds of millions of people with the ocean, and support a rich web of biodiversity throughout our oceans. But they are increasingly threatened with some areas reporting over 90% declines in kelp forest cover in living memory. Despite their importance and the threats they face, kelp...
Introducing Elinor for monitoring the governance and management of area‐based conservationNARA Subscribed
Monitoring the governance and management effectiveness of area‐based conservation has long been recognized as an important foundation for achieving national and global biodiversity goals and enabling adaptive management. However, there are still many barriers that prevent conservation actors, including those affected by governance and management systems from implementing conservation activities and programs and from gathering...