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Epistatic effects of IGHG and FCGRIIB genes on the development of Alzheimer’s disease in African AmericansNARA Subscribed
Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified a large number of susceptibility genes, but most of AD heritability remains unexplained, implying the existence of additional genes. Furthermore, the majority of the GWAS have been conducted in people of European descent, and the genes important for AD susceptibility in people of African descent have been underexplored. In this hypothesis-genera...
Accounting for human–nature linkages in area‐based conservation monitoring through social–ecological indicator bundlesNARA Subscribed
As the coverage of area‐based conservation increases across the globe, it is critical to improve understanding of the social and ecological outcomes of such measures and the pathways to their outcomes. A social–ecological systems approach to monitoring and evaluation is increasingly advocated; yet, applications remain scarce. We sought to facilitate operationalization of this approach through prioritization of indicators when...
Background Higher-risk medications are associated with increased risk of medication-related harm in older populations. Aim To investigate the association between socioeconomic status (SES) and the prescribing of higher-risk drug classes and polypharmacy in older community-dwelling adults. Methods This prospective, population-based cohort study used linked data from the Irish Longitudinal Study on Ageing (TILDA, 2018), the Heal...
Positive and negative impacts of electrical infrastructure on animal biodiversity: A systematic reviewNARA Subscribed
Electrical infrastructure networks are predicted to greatly expand in response to the expected 48% increase in global energy demand by 2040. While assessments of electrical infrastructure are abundant, mixed effects on animal diversity have been reported, warranting further evaluation to determine true effects. We conducted a systematic literature review covering individual, population, and community-level assessments to deter...
The sand lizard Lacerta agilis is a species of conservation concern in many areas, primarily due to habitat loss and fragmentation. Wildflower compensation areas, an increasingly widespread method of supporting biodiversity in intensive agricultural landscapes, could theoretically support L. agilis but may also act as an ecological trap. Using species distribution modelling, we estimated the relative habitat suitability for L....
Anopheles mosquitoes are major malaria vectors, encompassing several species complexes with diverse life histories, transmission risks and insecticide resistance profiles that challenge malaria control efforts. This study investigated the genetic structure and insecticide resistance profiles of Anopheles gambiae complex mosquitoes in Tanzania. We analysed whole‐genome sequence data of 300 mosquitoes collected between 2012 and...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Inequity is ubiquitous in the ocean, and social equity receives insufficient attention in ocean governance and management efforts. Thus, we assert that proponents of sustainability must center social equity in future ocean governance, to address past social and environmental injustices, to align with international law and conservation policy, and to realize objectives of sustainability. This obligation applies across all marin...
Motivation Pollinators play a crucial role in maintaining Earth's terrestrial biodiversity. However, rapid human‐induced environmental changes are compromising the long‐term persistence of plant‐pollinator interactions. Unfortunately, we lack robust, generalisable data capturing how plant‐pollinator communities are structured across space and time. Here, we present the EuPPollNet (European Plant‐Pollinator Networks) database,...
Challenges in assessing the effects of environmental governance systems on conservation outcomesNARA Subscribed
Effective governance is crucial for the success of conservation projects aimed at protecting wildlife populations and supporting human well‐being. However, few large‐scale, comprehensive syntheses have been conducted on the effects of different environmental governance types on conservation outcomes (i.e., biological and ecological effectiveness or effects of conservation on human well‐being), and clarity on the quantity and q...
Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α‐diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e., γ‐diversity), either due to reduced β‐diversity amplifying diversity loss or increased β‐diversity dampening diversity loss. Additionally, studies often focus on taxo...
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