Air pollution is a well-established risk factor for physical illness and premature mortality, yet its relationship with suicide remains less well understood, particularly at the national level and over longer periods of exposure. Although previous studies have reported positive associations between particulate matter and suicide, evidence remains heterogeneous, and national longitudinal analyses are limited. This study examine...

The aim of this study was to evaluate changes in 24-hour Holter electrocardiography parameters in French Bulldogs with nostril stenosis and elongated soft palate before and after corrective surgeries. Nine French Bulldogs diagnosed with brachycephalic syndrome (BOAS) were evaluated. Clinical evaluation involved a detailed anamnesis guided by literature-reported clinical signs, followed by a thorough physical examination of bot...

Small-scale fisheries play a key socioeconomic role in coastal systems, supporting livelihoods and providing essential marine ecosystem services. This role has been maintained and has evolved over time into a diverse portfolio of fishing techniques known as métiers , sustained through local ecological knowledge. But nowadays, climate change heavily threatens this fishing sector, compromising local knowledge and the well-being...

Purpose Irinotecan is widely used in metastatic colorectal cancer, but its clinical utility is limited by gastrointestinal toxicity, particularly intestinal mucositis, for which effective therapies are lacking. This study evaluated the protective effects of pioglitazone, a thiazolidinedione PPAR-γ agonist, against irinotecan-induced mucositis in female Swiss mice. Methods Mucositis was induced by irinotecan (75 mg/kg, i.p., fo...

Cancer biology is a constantly evolving field of study due to the dynamic and complex nature of biological systems. The unique role of in vitro assays in cell biology has led to numerous transformations in our understanding of the functional and structural details of the cells and tissues that comprise these systems. However, the traditional monolayer assays have been reported to fall short of the in vivo physiology of cells....

Benthic δ18O and δ13C values, as well as the mean grain size (MS) of sortable silt (SS), were used to construct the records of deep-water ventilation during the last 300 ka, at core GC02. This core is located at 4430 m water depth on the Madagascar basin near the Southwest Indian Ocean mid-ridge (SWIR). Decreased values of MS of SS reveal a weakened Antarctic Bottom Water (AABW) in the glacial periods, while increased values i...