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Cell–cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calciumNARA Subscribed
Tert -butyl hydroperoxide ( t -BuOOH) is an organic hydroperoxide widely used as a model compound to induce oxidative stress. It leads to a plethora of cellular damage, including lipid peroxidation, DNA double-strand breaks (DNA DSBs), and breakdown of the mitochondrial membrane potential (MMP). We could show in several cell lines that t -BuOOH induces ferroptosis, triggered by iron-dependent lipid peroxidation. We have furthe...
t-BuOOH induces ferroptosis in human and murine cell linesNARA Subscribed
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