Epigenomic changes are a hallmark of aging, and DNA methylation (DNAm) has emerged as the most reliable molecular marker of an individual's age. Genome‐wide patterns of age‐associated hypo‐ and hypermethylation have been applied to generate predictive models (i.e., “epigenetic clocks”) capable of estimating chronological age in an increasingly diverse set of species including many mammals, a few birds, a reptile, and several b...

Melanoma is a highly immunogenic malignancy with an elevated mutational burden, diffuse lymphocytic infiltration, and one of the highest response rates to immune checkpoint inhibitors (ICIs). However, over half of all late-stage patients treated with ICIs will either not respond or develop progressive disease. Spatial imaging technologies are being increasingly used to study the melanoma tumor microenvironment (TME). The goal...

By‐catch is the most significant direct threat marine megafauna face at the global scale. However, the magnitude and spatial patterns of megafauna by‐catch are still poorly understood, especially in regions with very limited monitoring and expanding fisheries. The Indian Ocean is a globally important region for megafauna biodiversity and for tuna fisheries, but has limited by‐catch data. Anecdotal and scattered information ind...

The most carbon (C)‐dense ecosystems of Amazonia are areas characterized by the presence of peatlands. However, Amazonian peatland ecosystems are poorly understood and are threatened by human activities. Here, we present an investigation into long‐term ecohydrological controls on C accumulation in an Amazonian peat dome. This site is the oldest peatland yet discovered in Amazonia (peat initiation ca. 8.9 ka BP ), and developed...

Species' ranges are shifting globally in response to climate warming, with substantial variability among taxa, even within regions. Relationships between range dynamics and intrinsic species traits may be particularly apparent in the ocean, where temperature more directly shapes species' distributions. Here, we test for a role of species traits and climate velocity in driving range extensions in the ocean‐warming hotspot of so...

The acquisition or designation of new protected areas is usually based on criteria for representation of different ecosystems or land‐cover classes , and it is unclear how well ‐ threatened species are conserved within protected‐area networks . Here , we assessed how Australia's terrestrial protected‐area system (89 million ha , 11 . 6% of the continent) overlaps with the geographic distributions of threatened species and comp...