The increase in fungal infections, the limited therapeutic arsenal, and the emergence of resistance pose a global health problem. Candida spp. stand out as opportunistic pathogens that cause superficial and invasive diseases. Thus, the search for new therapeutic alternatives, such as drug repositioning, is necessary. Duloxetine (DUL), a serotonin-norepinephrine reuptake inhibitor antidepressant used to treat depression, has de...

This pilot study evaluated the short- and mid-term outcomes of intra-articular allogeneic canine adipose-derived stem cell (ADSC) enriched secretome in dogs undergoing tibial plateau levelling osteotomy (TPLO), focusing on postsurgical recovery and osteoarthritis (OA) progression. Twenty client-owned dogs were randomly assigned ( n = 10 per group) to a control group (CG), receiving placebo, or a treated group (ADSC-Se), receiv...

Key message Field phenotyping of a recently established NAM population for stem rust resistance, combined with high-density genotyping, enabled the identification of novel sources of stem rust resistance in Italian ryegrass. Abstract Stem rust, caused by Puccinia graminis ssp. graminicola , is a major disease affecting the outcrossing species Italian ryegrass ( Lolium multiflorum Lam.) and leading to substantial reductions in...

Respiratory diseases remain a major public health challenge in tropical coastal cities, where persistent heat-humidity interactions and climate variability shape population vulnerability. This study quantified associations between atmospheric conditions and respiratory hospitalizations in Maceió, Brazil, using a 20-years time series (2000–2019). Weekly hospitalization rates stratified by age (children 0–4 years, adults 5–59 ye...

The genus Amblyomma koch, 1844 contains approximately 138 species, which are mainly distributed in the Afrotropical, Oriental, Neotropical and Australasian zoogeographic regions. This is an important group of arthropod vectors responsible for transmitting a wide range of etiological agents that cause infections and diseases in humans and animals, and is therefore of great interest to public and veterinary health.This study des...

β-Lapachone exhibits potent anticancer activity although its clinical application remains limited by toxicity and mechanisms of resistance. Therefore, structural modifications have been explored to improve its pharmacological profile. This study evaluated the cytotoxic, genotoxic, and toxicological effects of the oxime derivative β-lapachone oxime (Oxβ-Lp), together with its predicted pharmacokinetic properties and potential m...

Purpose Vascular dysfunction is a pathophysiological mechanism in peripheral artery disease (PAD). PAD patients exhibit reduced circulating expression of microRNA-126 (c-miRNA-126) and VEGF. Submaximal walking (SW) is recommended in PAD because it increases walking capacity, partially by improving vascular regulation, which can be observed after a walking session. Nevertheless, previous studies were conducted with maximal walk...

In its early years, the UN Decade on Ecosystem Restoration has mobilized unprecedented global commitments. Yet, measuring restoration success remains contested, particularly in megadiverse countries where the absence of standardized indicators and assessment protocols often leads to subjective decisions by environmental agencies. Here, we present a core set of leading indicators developed through a pioneering Brazil-led scienc...

Lake Baikal’s strictly seasonal, mostly frozen basin features prominently also in the social structures of Siberian indigenous communities, which consider it sacred. The lake’s complex occupation history, mainly from its western shore (Cis-Baikal), has been shaped by changing human-animal-environment interaction dynamics, including relationships with the world’s single exclusively freshwater pinniped species, Pusa sibirica Gme...