The objective was to analyze the mRNA expression of leptin, leptin receptor (ObRb), adiponectin, adiponectin receptor (AdipoR1), and resistin in the placental tissue of cows with and without hyperketonemia, relating it to their metabolic profile. Samples were collected from 135 cows during birth, divided into two groups: G1: without hyperketonemia ( n = 120) and G2: with hyperketonemia ( n = 15). Biochemical and hormonal indic...

Purpose Dysphagia in neurological patients complicates oral drug administration. Manual preparation of lozenges/troches lacks precision and scalability. This study investigates the feasibility of implementing a pharmaceutical 3D printer in a hospital pharmacy for the automated production of personalized baclofen troches. Methods Baclofen troches were manufactured in a hospital pharmacy setting, both manually and via pharmaceut...

The genus Amblyomma koch, 1844 contains approximately 138 species, which are mainly distributed in the Afrotropical, Oriental, Neotropical and Australasian zoogeographic regions. This is an important group of arthropod vectors responsible for transmitting a wide range of etiological agents that cause infections and diseases in humans and animals, and is therefore of great interest to public and veterinary health.This study des...

Understanding how local environmental factors and seasonal variation shape aquatic insect communities is key for developing effective biomonitoring tools, especially in ecotonal regions undergoing rapid environmental changes such as the Brazilian Cerrado. In this study, we tested the hypotheses that (1) local environmental variables exert stronger influence than seasonality on EPT composition and (2) environmental gradients de...