Daniel Gilbert results 63
· Newest (Page 1/3, per page 25)
Author: Daniel Gilbert ×Clear All Filters
Search Results
PQRI Workshop: Model-Informed Drug Development (MIDD) Approaches in Pediatric Formulation DevelopmentNARA Subscribed
In February of 2024, the Product Quality Research Institute held a virtual workshop entitled “Model-Informed Drug Development (MIDD) Approaches in Pediatric Formulation Development.” The workshop covered a range of topics related to pediatric formulation development and testing, including dissolution testing and applications to modeling drug absorption in developing pediatric patients. Workshop speakers reviewed the progress t...
Changes in Key Biodiversity Area networks following national comprehensive assessmentsNARA Subscribed
Key Biodiversity Areas (KBAs) are sites of significance for the global persistence of biodiversity. Based on the Global Standard for the Identification of Key Biodiversity Areas (KBA Standard), published in 2016, sites are currently being assessed for KBA designation in a growing number of countries across the world. For these assessments, the KBA criteria are applied to all species and ecosystems with available data. We revie...
Resilient plants, sustainable futureNARA Subscribed
Host Species–Microbiome Interactions Contribute to Sphagnum Moss Growth Acclimation to WarmingNARA Subscribed
Sphagnum moss is the dominant plant genus in northern peatlands responsible for long‐term carbon accumulation. Sphagnum hosts diverse microbial communities (microbiomes), and its phytobiome (plant host + constituent microbiome + environment) plays a key role in nutrient acquisition along with carbon cycling. Climate change can modify the Sphagnum ‐associated microbiome, resulting in enhanced host growth and thermal acclimation...
The Relationship Between Maturation Size and Maximum Tree Size From Tropical to Boreal ClimatesNARA Subscribed
The fundamental trade‐off between current and future reproduction has long been considered to result in a tendency for species that can grow large to begin reproduction at a larger size. Due to the prolonged time required to reach maturity, estimates of tree maturation size remain very rare and we lack a global view on the generality and the shape of this trade‐off. Using seed production from five continents, we estimate tree...
Ericoid shrub encroachment shifts aboveground–belowground linkages in three peatlands across Europe and Western SiberiaNARA Subscribed
In northern peatlands, reduction of Sphagnum dominance in favour of vascular vegetation is likely to influence biogeochemical processes. Such vegetation changes occur as the water table lowers and temperatures rise. To test which of these factors has a significant influence on peatland vegetation, we conducted a 3‐year manipulative field experiment in Linje mire (northern Poland). We manipulated the peatland water table level...
Linking seed size and number to trait syndromes in treesNARA Subscribed
Aim Our understanding of the mechanisms that maintain forest diversity under changing climate can benefit from knowledge about traits that are closely linked to fitness. We tested whether the link between traits and seed number and seed size is consistent with two hypotheses, termed the leaf economics spectrum and the plant size syndrome, or whether reproduction represents an independent dimension related to a seed size–seed n...
Globally, tree fecundity exceeds productivity gradientsNARA Subscribed
Lack of tree fecundity data across climatic gradients precludes the analysis of how seed supply contributes to global variation in forest regeneration and biotic interactions responsible for biodiversity. A global synthesis of raw seedproduction data shows a 250‐fold increase in seed abundance from cold‐dry to warm‐wet climates, driven primarily by a 100‐fold increase in seed production for a given tree size. The modest (three...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
In this paper, we outline the need for a coordinated international effort toward the building of an open-access Global Ocean Oxygen Database and ATlas (GO 2 DAT) complying with the FAIR principles (Findable, Accessible, Interoperable, and Reusable). GO 2 DAT will combine data from the coastal and open ocean, as measured by the chemical Winkler titration method or by sensors (e.g., optodes, electrodes) from Eulerian and Lagrang...
Animal Borne Ocean Sensors – AniBOS – An Essential Component of the Global Ocean Observing SystemOA Marine
Marine animals equipped with biological and physical electronic sensors have produced long-term data streams on key marine environmental variables, hydrography, animal behavior and ecology. These data are an essential component of the Global Ocean Observing System (GOOS). The Animal Borne Ocean Sensors (AniBOS) network aims to coordinate the long-term collection and delivery of marine data streams, providing a complementary ca...
Modeling of retrospectively collected multi-center data of a rare disease in pediatrics is challenging because laboratory data can stem from several decades measured with different assays. Here we present a retrospective pharmacometrics (PMX) based data analysis of the rare disease congenital hypothyroidism (CH) in newborns and infants. Our overall aim is to develop a model that can be applied to optimize dosing in this pediat...