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Continuous Distillation for Drug Substance ManufacturingNARA Subscribed
Purpose Continuous distillation is widely used in the commodity and petrochemical industry to purify fine chemicals on massive industrial scales; however, this key separation strategy is largely unused within the pharmaceutical industry. This article investigates the development of a pilot-scale continuous distillation system for in-line removal of an excess amine reactant ( i.e. , tert-butylamine) when incorporated within an...
Controversy and consensus: common ground and best practices for life cycle assessment of emerging technologiesNARA Subscribed
Public and private interest in life cycle assessment (LCA) has grown as environmental disclosure norms tighten, driving demand for decision-relevant assessment early in technological development cycles. Early-stage LCA has the potential to guide design choices, steer innovation, and mitigate lock-in of adverse environmental impacts. However, many aspects of early-stage LCA practice remain unsettled. We convened experts in a se...
Soil Microbial Diversity and Network Organization Respond to Land Use and Agricultural Inputs WorldwideNARA Subscribed
Soil microbiomes are critical for ecosystem functioning, yet the global influences of climate and agricultural practices on their diversity and structure remain incompletely characterized. Here we analyzed 1921 soil samples from 33 countries worldwide across diverse biomes to assess how climate gradients and agricultural inputs, including pesticides and fertilizers, shape prokaryotic and fungal communities. We found that micro...
Global patterns and regional insights into kelp forest protection, restoration, and stewardshipNARA Subscribed
Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...
The presence of an atavistic caniniform alveolus in Nothrotherium maquinense (Xenarthra, Folivora, Nothrotheriidae)NARA Subscribed
Sloths (Folivora) display remarkable morphological diversity yet share a highly conserved dental formula, whose occasional deviations offer key insights into their evolutionary history. Among nothrotheriids, Neogene species retained upper and lower caniniforms, whereas these teeth were lost in Pleistocene genera. Here we describe, for the first time, a poorly developed alveolus interpreted as an atavistic upper caniniform alve...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Mapping the Distribution and Conservation Status of Mature and Old Growth Forests Across Coastal Alaska and British ColumbiaNARA Subscribed
Old growth forests in coastal Alaska and British Columbia represent some of the most expansive temperate rainforests on Earth, supporting high biodiversity, substantial carbon stocks, and the cultural heritage of Indigenous communities. Despite their importance, spatially consistent information on the distribution of old growth and mature forests in this region remains limited. We addressed this gap by integrating data across...
Tidal Forested Wetlands Can Be Incorporated into Blue Carbon Conservation and Restoration StrategiesNARA Subscribed
Purpose of Review Blue carbon is an important concept for environmental policy. Blue carbon strategies (conservation and restoration for carbon gain) have been primarily implemented with mangroves, though are likely to be suitable for other tidal forested wetlands. Here, we discuss the expanding definition of blue carbon encompassing all tidal forested wetlands, synthesize ecological and carbon sink knowledge of tidal forested...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...