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A nonlinear windkessel model for cardiovascular dynamics: Variable compliance and pathological simulationsNARA Subscribed
Lumped-parameter cardiovascular models are computationally efficient and physiologically interpretable, but many still represent arterial compliance as linear and pressure-independent. Here, we introduce a nonlinear extension of a classical closed-loop Windkessel model by defining aortic compliance as an exponential function of aortic pressure. The heart, systemic circulation, and pulmonary circulation are represented as an RL...
Genomic Signatures of Microgeographic Adaptation in Anopheles coluzzii Across Urban, Rural, and Forested Environments in GabonNARA Subscribed
Species distributed across heterogeneous environments often evolve locally adapted populations, but understanding how these persist in the presence of homogenizing gene flow remains puzzling. In Gabon, Anopheles coluzzii, a major African malaria mosquito, is found in various ecological settings, including urban areas, remote rural villages, and forested environments away from any human presence. This study investigates the gen...
Oral lipoteichoic and lipoic acids improve insulin resistance and body composition in porphyria mice on a high-carbohydrate dietNARA Subscribed
Acute intermittent porphyria (AIP) is a genetic metabolic disorder characterized by neurovisceral attacks. Although high-carbohydrate diets or intravenous glucose administration can help alleviate incipient attacks in patients, these interventions may also promote insulin resistance and increase metabolic risk. This study explored targeted dietary interventions to manage hyperinsulinemia and to enhance glucose uptake in insuli...
Requirements for a fishery to achieve Marine Stewardship Council (MSC) certification include demonstrating that targeted populations (‘MSC stocks’) are fished at sustainable levels. The credibility of this claim can be evaluated by comparing estimated abundance of MSC stocks to benchmarks based on sustainability criteria. Additionally, to evaluate whether MSC certification provides a meaningful distinction, the sustainability...
Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyon...
Fishery managers must often reconcile conflicting estimates of population status and trend. Superensemble models, commonly used in climate and weather forecasting, may provide an effective solution. This approach uses predictions from multiple models as covariates in an additional “superensemble” model fitted to known data. We evaluated the potential for ensemble averages and superensemble models (ensemble methods) to improve...
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