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A nonlinear windkessel model for cardiovascular dynamics: Variable compliance and pathological simulationsNARA Subscribed
Lumped-parameter cardiovascular models are computationally efficient and physiologically interpretable, but many still represent arterial compliance as linear and pressure-independent. Here, we introduce a nonlinear extension of a classical closed-loop Windkessel model by defining aortic compliance as an exponential function of aortic pressure. The heart, systemic circulation, and pulmonary circulation are represented as an RL...
Purpose Despite persistent bleeding and thrombotic adverse events in patients supported with blood pumps, standardized preclinical assessment of hemocompatibility remains largely restricted to hemolysis testing. To advance the field, robust and comparable in vitro platelet function testing within mock-loop mechanical circulatory support (MCS) studies is needed. This review systematically summarizes current methodologies for pl...
Post-prandial acyl ghrelin infusion in heart failure patients increases gastric emptying rateNARA Subscribed
Acyl ghrelin increases cardiac output (CO) and contractility in patients with heart failure with reduced ejection fraction (HFrEF). In healthy humans, acyl ghrelin increases gastric emptying rate (GER) and hunger, a potential add-on benefit for HFrEF patients suffering from cachexia with symptoms of delayed gastric emptying and loss of appetite. The aim of this study was to determine if post-prandial acyl ghrelin infusion incr...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Biogeography and Anthropogenic Development Shape Mesopredator Distributions in a Rapidly Developing RegionNARA Subscribed
Aim To investigate effects of anthropogenic development at regional and landscape scales on the distributions of mid‐trophic level mammalian predators (mesopredators) across the southeastern United States. Location The study area encompasses seven ecoregions across a large portion of the southeastern United States. Taxon Mammalian mesopredators. Methods We compiled trail camera data from 21 studies across the southeastern Unit...
Molecular Footprints of Quaternary Climate Fluctuations in the Circumpolar Tundra Shrub Dwarf BirchNARA Subscribed
The Arctic tundra biome is undergoing rapid shrub expansion (‘shrubification’) in response to anthropogenic climate change. During the previous ~2.6 million years, glacial cycles caused substantial shifts in Arctic vegetation, leading to changes in species' distributions, abundance and connectivity, which have left lasting impacts on the genetic structure of modern populations. Examining how shrubs responded to past climate ch...
Purpose We aimed to quantitatively compare different computed tomography (CT)-based bone volume fraction (BV/TV) measurements. We hypothesize that phantom-less measurement using virtual monochromatic images (VMI) reconstructed form dual-energy CT (DECT) or photon counting CT (PCT) is less affected by tissue variations in trabecular bone than quantitative CT (QCT) and that PCT allows measurements with a lower radiation dose. Me...
Human sperm as an in vitro toxicity model: a versatile tool for assessing the risk of environmental contaminantsNARA Subscribed
Contaminants of emerging concern (CECs) pose a significant threat to human and ecosystem health due to their persistence, bioaccumulation in higher trophic levels, and potential toxicity. While in vivo models are commonly used for toxicity screening, developing alternative in vitro techniques for rapid environmental risk assessment is essential. Spermatozoa, with their compartmentalized structure, measurable characteristics an...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Aim The urgency for remote, reliable and scalable biodiversity monitoring amidst mounting human pressures on ecosystems has sparked worldwide interest in Passive Acoustic Monitoring (PAM), which can track life underwater and on land. However, we lack a unified methodology to report this sampling effort and a comprehensive overview of PAM coverage to gauge its potential as a global research and monitoring tool. To address this...