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Limitations of using the canopy to infer the structure and functioning of giant kelp forestsOA Marine
Data obtained from remote sensing of floating kelp canopies are routinely used to assess changes in the distribution, structure and functioning of kelp forests. Such assessments rely on the assumption that changes in surface canopies reflect changes in the structure and functioning of the underlying kelp forests. So far there has been little attempt to validate this assumption, which raises the risk that management decisions p...
Submaximal walking increases MicroRNA-126 and angiogenic markers in men and women with peripheral arterial diseaseNARA Subscribed
Purpose Vascular dysfunction is a pathophysiological mechanism in peripheral artery disease (PAD). PAD patients exhibit reduced circulating expression of microRNA-126 (c-miRNA-126) and VEGF. Submaximal walking (SW) is recommended in PAD because it increases walking capacity, partially by improving vascular regulation, which can be observed after a walking session. Nevertheless, previous studies were conducted with maximal walk...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Seasonal Occurrence and Behavior of an Endangered Franciscana Dolphin ( Pontoporia blainvillei pukusi ) PopulationNARA Subscribed
The franciscana dolphin ( Pontoporia blainvillei ) is a threatened cetacean whose northernmost population (Franciscana Management Area Ia)—part of the recently described subspecies P. b. pukusi— faces significant anthropogenic pressures, including impacts from a major mining dam collapse. However, fundamental data on its seasonal ecology remain scarce. This study aimed to investigate the seasonal variation in occurrence, group...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Efficacy of Inhalable Endolysin Cpl-1 Formulations in Combination with Gentamicin or Endolysin Pal in a Murine Lung Infection ModelNARA Subscribed
Purpose Inhalable liquid formulation of endolysins represents a promising alternative to conventional antibiotics. Dry powder formulations offer improved stability for endolysin pulmonary delivery. This study aimed to evaluate the efficacy of an inhalable dry powder or liquid formulation of endolysin Cpl-1 alone and to compare it with liquid combinations of Cpl-1 with either gentamicin or endolysin Pal in a murine model of S....
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Despite extensive research on life-extending interventions, rigorous statistical techniques to determine their impact on compression of morbidity (CoM) are rarely used. We present a case example of an analytical method for examining the effect of life-extending dietary interventions on CoM by comparing the rates of decline in vitality and survival toward the end of life. Using data from previous experimental studies in mice, w...