The present study aimed to comprehensively characterize the cancer-associated virome in patients with gastric cancer. A total of 452 samples were analyzed, including 226 tumor tissues and 202 peritumoral tissues from patients undergoing surgical resection, alongside 24 normal gastric mucosa samples obtained via endoscopy from individuals without cancer. RNA was extracted, libraries were prepared, and paired-end sequencing was...

The objective was to analyze the mRNA expression of leptin, leptin receptor (ObRb), adiponectin, adiponectin receptor (AdipoR1), and resistin in the placental tissue of cows with and without hyperketonemia, relating it to their metabolic profile. Samples were collected from 135 cows during birth, divided into two groups: G1: without hyperketonemia ( n = 120) and G2: with hyperketonemia ( n = 15). Biochemical and hormonal indic...

Three new isatin–pyridine-2-oxime hybrids (AM01–03) were synthesized and experimentally evaluated as reactivators of acetylcholinesterase (AChE) inhibited by a surrogate of the nerve agent A-242, in comparison with their 4-oxime isomers previously reported by our research group. Furthermore, the interactions of these molecules within the AChE/A-242 complex were assessed through docking and molecular dynamics (MD) simulations....

Reliable soil water balance models are needed for sugarcane water management under rainfed and non-standard field conditions. This study optimized crop coefficients and assessed the Thornthwaite and Mather Crop (ThM) and FAO-56 dual-Kc models for estimating daily and 10-day soil water content (θ) and actual evapotranspiration (ET a ) in rainfed sugarcane in Alagoas State, Brazil. Field θ was measured with a reflectometry probe...

The genus Amblyomma koch, 1844 contains approximately 138 species, which are mainly distributed in the Afrotropical, Oriental, Neotropical and Australasian zoogeographic regions. This is an important group of arthropod vectors responsible for transmitting a wide range of etiological agents that cause infections and diseases in humans and animals, and is therefore of great interest to public and veterinary health.This study des...

Understanding the links between metabolism, ageing, and age-related phenotypes may clarify the role of ageing in disease onset and improve risk prediction. We conducted a cross-cohort assessment of biological age using broad-spectrum LC–MS metabolomics of 3,686 plasma samples in 2,295 participants, aged 20–89, from the UK Airwave study ( N = 960) and the Irish Longitudinal Study of Ageing ( N = 1,335). The nucleoside N 2 ,N 2...

Soil microbiomes are critical for ecosystem functioning, yet the global influences of climate and agricultural practices on their diversity and structure remain incompletely characterized. Here we analyzed 1921 soil samples from 33 countries worldwide across diverse biomes to assess how climate gradients and agricultural inputs, including pesticides and fertilizers, shape prokaryotic and fungal communities. We found that micro...

Glycine is a fundamental neuroactive amino acid that serves dual roles in the central nervous system: acting as a primary inhibitory neurotransmitter via strychnine-sensitive glycine receptors and as an essential co-agonist at the N-methyl-D-aspartate (NMDA) receptor. This dual functionality is important for maintaining the excitation–inhibition balance, synaptic plasticity, and network stability. The spatial and temporal avai...

WHO ranked chronic inflammatory diseases as the most significant cause of death. The current therapeutic approach is the constant administration of clinically available anti-inflammatory drugs; however, this strategy presents severe side effects. New entities derived from plants have shown their potential for developing safe and effective therapies. Particularly, Echinacea purpurea extracts have demonstrated strong anti-inflam...

The wild boar population in Europe has been growing in recent decades prior to the arrival of African swine fever (ASF), which has now spread across much of eastern Europe. We obtained two independent sources of wild boar data: occurrence sightings and hunting harvest. We combined these with environmental predictors and used them in two species distribution modelling approaches, a Maxent approach for occurrence data and a GLMM...

The body size spectrum (or individual size distribution) is a simple yet widely recognized approach that links individual and population traits to community structure and ecosystem functions, making it a valuable indicator of anthropogenic effects. However, the assessment of size spectra in the context of biological invasions remains poorly explored. We investigated the impacts of non‐native (NN) fish invasions on the size str...