Age is a well-known risk factor to develop severe viral respiratory infections, including severe COVID-19. This study aimed to identify the biological alterations linked to severe disease in elderly patients with COVID-19. For this purpose, we employed a derivation cohort with 450 SARS-CoV-2 infected and unvaccinated patients admitted to hospital wards and a validation cohort with 244 SARS-CoV-2 infected and unvaccinated patie...

Anchialine caves are singular aquatic environments of significant conservation interest, defined by darkness, constant temperature, and low levels of nutrients and dissolved oxygen, as well as vertically stratified water layers. Due to their challenging accessibility, these caves represent one of the few remaining unexplored frontiers on Earth, hosting short-range endemics and ecologically specialized communities highly suscep...