The increase in fungal infections, the limited therapeutic arsenal, and the emergence of resistance pose a global health problem. Candida spp. stand out as opportunistic pathogens that cause superficial and invasive diseases. Thus, the search for new therapeutic alternatives, such as drug repositioning, is necessary. Duloxetine (DUL), a serotonin-norepinephrine reuptake inhibitor antidepressant used to treat depression, has de...

Objectives This study investigated the helminth fauna of Serrasalmus maculatus and Serrasalmus marginatus in a protected area (Santa Helena Biological Refuge) and in the lower São Francisco Falso River, Brazil. The main objective was to compare the parasitic helminth fauna of these species between the areas of occurrence and to develop an updated list of the recorded parasite species. Methods Fifty individuals of each host spe...

This study evaluated the reliability of functional data imputed in the classification of ecological strategies according to the CSR model (competitive, stress-tolerant, ruderal) in tree species of a riparian Atlantic Forest in Brazil. Empirical data collected in situ from 68 species were compared with data imputed using the Bayesian Hierarchical Probabilistic Matrix Factorization (BHPMF) technique, considering key functional a...

Optimizing maize–Brachiaria intercropping requires effective weed management with selective maize herbicides. This study evaluated the spray performance and efficacy of atrazine + nicosulfuron for weed management in maize–Brachiaria intercropping, focusing on how droplet classes and spray volumes affect maize growth and yield. The deposition experiment was conducted in a greenhouse in a completely randomized design with six re...

Urban freshwater ecosystems are increasingly exposed to mixtures of pollutants, including per- and polyfluoroalkyl substances (PFAS). However, their ecological effects remain poorly understood, especially in tropical regions with limited sanitation infrastructure. This study investigated PFAS contamination, water quality, and microbial community structure in Pampulha Lake, a tropical urban reservoir in southeastern Brazil. Spa...

Tumor progression depends on an adequate blood supply to sustain oxygen and nutrients delivery. While tumor angiogenesis involves the formation of new blood vessels from pre-existing ones, vessel co-option represents a non-angiogenic vascularization strategy whereby tumor cells utilize pre-existing host vessels. Co-opted vessels have been considered refractory to anti-angiogenic therapies, and pharmacological modulation of co-...

Respiratory diseases remain a major public health challenge in tropical coastal cities, where persistent heat-humidity interactions and climate variability shape population vulnerability. This study quantified associations between atmospheric conditions and respiratory hospitalizations in Maceió, Brazil, using a 20-years time series (2000–2019). Weekly hospitalization rates stratified by age (children 0–4 years, adults 5–59 ye...

Climatotherapy (including thalassotherapy, sun exposure, and marine mud therapy) has long been used as a complementary intervention for musculoskeletal and rheumatologic disorders (MSRDs), yet its evidence base remains fragmented and methodologically heterogeneous. To synthesize the effectiveness and safety of climatotherapy in marine or Dead Sea environments for MSRDs, focusing on pain, physical function, and health-related q...

The genus Amblyomma koch, 1844 contains approximately 138 species, which are mainly distributed in the Afrotropical, Oriental, Neotropical and Australasian zoogeographic regions. This is an important group of arthropod vectors responsible for transmitting a wide range of etiological agents that cause infections and diseases in humans and animals, and is therefore of great interest to public and veterinary health.This study des...

Accurate detection of high-risk human papillomavirus (HPV) is central to cervical cancer screening. Current diagnostic strategies increasingly prioritize broad-spectrum assays to maximize genotype coverage. However, theoretical genotype breadth does not necessarily translate into effective sample-level detection when clinically dominant targets are present at low copy number. Here, we evaluated this analytical trade-off using...

Trachelyopterus is a cryptic genus within the Neotropical catfish family Auchenipteridae with a complex history of taxonomic revisions. Despite the notable morphological and genetic similarities among its species, some studies suggest that the genus harbours greater diversity than is currently recognized, including additional species yet to be formally described. One of the most widely used and effective approaches for investi...