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Unveiling the Viral Landscape in Gastric CancerNARA Subscribed
The present study aimed to comprehensively characterize the cancer-associated virome in patients with gastric cancer. A total of 452 samples were analyzed, including 226 tumor tissues and 202 peritumoral tissues from patients undergoing surgical resection, alongside 24 normal gastric mucosa samples obtained via endoscopy from individuals without cancer. RNA was extracted, libraries were prepared, and paired-end sequencing was...
Main conclusion Trait development for commercial heirloom tomatoes can be advanced by optimization of tissue culture and transformation via Agrobacterium and CRISPR/Cas9 mutagenesis. Abstract Genetic improvement using new genome editing approaches relies on the efficient delivery of the CRISPR/Cas system in the vegetable crop tomato. Previous protocols for tomato transformation have primarily focused on a handful of cultivars...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...