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Purpose Unrecognized contraindications pose risks for adverse drug reactions, hospitalizations or death. Clinical decision support systems (CDSS) aim to mitigate medication-related harm, particularly originating from contraindications. However, many CDSS provide limited benefit, as they focus largely on singular risk situations such as drug-drug interactions and often generate alerts of limited clinical relevance. Comprehensiv...
Same Test, Different Stories? A Critical Look at vLamax Modality-Specific ReliabilityNARA Subscribed
Background The maximal rate of blood lactate accumulation ( v La max ) is increasingly used as a marker of anaerobic glycolytic performance in various sports. Despite its conceptual relevance, the methodological robustness and reliability of current v La max testing protocols remain unclear. Objective This systematic review critically examines the reliability of v La max across different exercise modalities and evaluates the m...
Next-generation broad-spectrum reactivators for effective countermeasure against organophosphorus poisoningNARA Subscribed
Sustained effort has been dedicated to the development of novel cholinesterase reactivators—the only causal antidotes—to counter organophosphorus (OP) intoxication. As more lethal nerve agents—such as A-agents—continue to emerge, the existing arsenal of causal antidotes remains unchanged. Approved oxime reactivators— 2-PAM , HI-6 , and LüH-6 —are restricted by their limited efficacy spectrum, poor blood–brain barrier permeabil...
Bridging the Energy Balance Gap in Eddy‐Covariance Measurements: Insights From Standardized Network DataNARA Subscribed
The lack of energy balance closure in Eddy‐Covariance (EC) measurements is a well‐known, still unresolved challenge in micrometeorology, with energy balance closure (EBC) rates typically ranging between 60% and 80%. While numerous hypotheses have been proposed to explain this imbalance, the relative contributions of neglected energy storage terms, data quality and flux processing options remain insufficiently disentangled. Usi...
Through genomic phylogeography, previously unrecognised biodiversity can be revealed. The alpine newt serves as a case in point: this taxon carries highly distinct mtDNA clades and has a severely fragmented range. We obtain genome‐wide data with target enrichment by sequence capture to delineate cryptic species and disentangle their phylogenetic relationships. Furthermore, we explore potential niche divergence and glaciation‐d...
Local and Landscape‐Level Environmental Conditions Drive Habitat Selection Across Terrestrial Mammal SpeciesNARA Subscribed
Aim Animal movements are a fundamental process affecting communities and ecosystems. Quantifying habitat selection across species and habitats is key for understanding how animals respond to environmental change. Currently, we lack comparative studies that examine how habitat selection varies across species traits and landscapes. We aim to quantify global patterns of habitat selection to help understand the fundamental drivers...