Tumor progression depends on an adequate blood supply to sustain oxygen and nutrients delivery. While tumor angiogenesis involves the formation of new blood vessels from pre-existing ones, vessel co-option represents a non-angiogenic vascularization strategy whereby tumor cells utilize pre-existing host vessels. Co-opted vessels have been considered refractory to anti-angiogenic therapies, and pharmacological modulation of co-...

Purpose Dysphagia in neurological patients complicates oral drug administration. Manual preparation of lozenges/troches lacks precision and scalability. This study investigates the feasibility of implementing a pharmaceutical 3D printer in a hospital pharmacy for the automated production of personalized baclofen troches. Methods Baclofen troches were manufactured in a hospital pharmacy setting, both manually and via pharmaceut...

Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...

Aims The incorporation of Plant Growth-Promoting Bacteria (PGPB) into compost is a promising strategy to enhance the potential of organic fertilizers. This study investigates in a pot experiment the potential of hydrogel capsules containing a PGPB consortium to improve compost efficiency, promote crop growth, and increase nutrient uptake. Methods Three PGPB strains ( Rhizobium leguminosarum T88, Herbaspirillum frisingense AP21...

The invasive brown seaweed Rugulopteryx okamurae represents an ecological challenge in European and Mediterranean coasts. We propose valorizing the biomass collected by incorporating it as a feed ingredient into sustainable aquafeeds. This study evaluated the effects of administering a pulse of biotechnologically treated R. okamurae biomass on muscle composition, gene expression, and intestinal microbiota in the mullet, Chelon...

Human‐induced high densities of large wild herbivores may pose a threat to natural ecosystems, modifying biodiversity and ecosystem functioning. Although the negative impacts on individual taxa and processes are well documented, a comprehensive understanding of how ecosystem integrity responds to high herbivore densities remains limited. This study addresses this gap through an extensive herbivore‐density manipulation experime...