Biometals such as iron, copper, zinc, manganese, cobalt, and selenium play crucial roles in cellular respiration, immunity, apoptosis, and signaling. However, their excessive accumulation can induce chronic inflammation, oxidative stress, and trigger carcinogenesis. Iron addiction stands out for its importance in tumor cell replication and survival. Cancer remains one of the leading causes of mortality worldwide. Given the lim...

Since the 1990s, Acinetobacter baumannii has become a major global concern owing to its high incidence in hospital-acquired infections. Although antimicrobial resistance is a natural process, it has been enhanced by the widespread use of antimicrobials in human and animal healthcare and is considered a global priority in the development of new drugs. Therefore, antibacterial photodynamic therapy has gained prominence for treat...

Cooling towers (CTw) are essential for industrial refrigeration but provide favourable conditions for microbial growth and biofilm formation, potentially facilitating the spread of antimicrobial-resistant bacteria (ARB). This study examines bacterial diversity, biofilm potential and antimicrobial susceptibility in two industrial CTw in Brazil using culture-based and metataxonomic (16 S rRNA gene amplicon sequencing) approaches...

In the face of climate change, agricultural modelling combined with experimental research is essential for predicting yields in diverse climatic scenarios. This study calibrated, validated and applied the AquaCrop model for forage sorghum under future climate scenarios in a semi‐arid region between 2020 and 2022. Meteorological data, soil moisture, canopy cover and crop productivity were collected. Model performance was evalua...

Aquaculture effluents are increasingly recognized as a strategic resource for agricultural water reuse, especially in semi-arid regions, where water scarcity and fertilizer costs intensify pressure on production systems. Within a circular economy framework, these effluents may simultaneously supply water and nutrients; however, their physicochemical composition must be carefully assessed, since excessive salt loading may impai...

Many urban parks in large cities are created to promote human recreation and well-being by offering nature-like environments. Over time, urban-tolerant birds establish populations in these spaces. Although strengthening citizens’ connections with urban birds may enhance park-related well-being, it remains a central question whether visit frequency among the general public (i.e., non-birders) increases their perception and inte...

Cell fate determination and terminal differentiation are shaped by intrinsic molecular programs that coordinate lineage-specific gene expression. In mesenchymal stem cells (MSCs), variability in osteogenic efficiency among distinct tissue sources remains poorly understood and cannot be fully explained by differentiation conditions alone. Increasing evidence indicates that post-transcriptional regulatory mechanisms, particularl...

Wildfire smoke represents an underrecognized yet potentially important contributor to the dissemination of antimicrobial resistance (AMR). As wildfires increase in frequency and intensity due to climate change, they release vast amounts of PM 2.5 , particles with the potential to transport antimicrobial-resistant microorganisms and genetic elements across long distances. These severe air pollution events create multifactorial...

This study investigates the impact of a 16-week mixed circuit training (MCT) program on purinergic signaling and oxidative stress markers in women with type 2 diabetes mellitus (T2DM), focusing on its potential to modulate platelet-related purinergic signaling and oxidative stress markers that are mechanistically linked to platelet activation. A total of 21 women with T2DM and 23 non-diabetic controls, all sedentary and middle...

The incidence of brain diseases increases with aging, but the biological basis of brain aging is still poorly explored. Synaptic dysfunction occurs at the onset of brain diseases and synaptic neuromodulation systems, such as adenosine A 2A receptors (A 2A R), are necessary and sufficient to trigger brain dysfunction. Since A 2A R are upregulated upon aging, we compared wild-type and A 2A R global knockout mice to test if brain...

Air pollution remains a persistent environmental and public health concern in urban regions. This study presents a 22-year analysis (2001–2022) of coarse particulate matter (PM 10 ) concentrations across 15 monitoring stations in the Porto Metropolitan Area (PMA), Portugal. The stations, pre-classified by national authorities as traffic, background-urban, background-suburban, or industrial, were used to assess long-term tempor...

Forage production in semi‐arid regions of Brazil is limited by water deficit. This study aimed to identify the most adapted and efficient production systems and define their agricultural calendars for the semi‐arid region of Brazil. Twenty‐nine production arrangements that included different cropping conditions, plant density, plant cycles, water replenishment, use of soil cover and production arrangements based on the main cr...