Danielle Edwards results 33
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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Biodiversity conservation in northern Australia is characterised by high endemism, data deficiency, and high Indigenous land tenure and population. The Northern Australia Conservation Genomics Forum brought together experts to explore current genetic research with particular emphasis on integration of genomics within conservation practices. We discuss the regional biodiversity of northern Australia, highlighting the unique bio...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Coral reef attributes associated with microplastic exposureNARA Subscribed
Coral reef declines have been documented since the 1980’s from a variety of global and local stressors. Management resource tools are needed to preserve these fragile ecosystems from stressors, both known and unknown. Laboratory studies have shown microplastics (MP) to have negative effects on coral physiology, but their effects in a natural environment are not well understood. Thus, our primary objectives were to explore asso...
Recent extremes of flood and drought across Australia have raised questions about the recurrence of such rare events and highlighted the importance of understanding multi-decadal climate variability. However, instrumental records over the past century are too short to adequately characterise climate variability on multi-decadal and longer timescales or robustly determine extreme event frequencies and their duration. Palaeoclim...
Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio RerioNARA Subscribed
Actin, tropomyosin and troponin, the proteins that comprise the contractile apparatus of the cardiac thin filament, are highly conserved across species. We have used cryo-EM to study the three-dimensional structure of the zebrafish cardiac thin and actin filaments. With 70% of human genes having an obvious zebrafish orthologue, and conservation of 85% of disease-causing genes, zebrafish are a good animal model for the study of...
To determine the drivers of phytoplankton biomass, we collected standardized morphometric, physical, and biological data in 230 lakes across the Mediterranean, Continental, and Boreal climatic zones of the European continent. Multilinear regression models tested on this snapshot of mostly eutrophic lakes (median total phosphorus [TP] = 0.06 and total nitrogen [TN] = 0.7 mg L −1 ), and its subsets (2 depth types and 3 climatic...
Testing a global standard for quantifying species recovery and assessing conservation impactNARA Subscribed
Recognizing the imperative to evaluate species recovery and conservation impact, in 2012 the International Union for Conservation of Nature (IUCN) called for development of a “Green List of Species” (now the IUCN Green Status of Species). A draft Green Status framework for assessing species’ progress toward recovery, published in 2018, proposed 2 separate but interlinked components: a standardized method (i.e., measurement aga...
The extracellular matrix fragment perlecan domain V is neuroprotective and functionally restorative following experimental stroke. As neurogenesis is an important component of chronic post-stroke repair, and previous studies have implicated perlecan in developmental neurogenesis, we hypothesized that domain V could have a broad therapeutic window by enhancing neurogenesis after stroke. We demonstrated that domain V is chronica...
Lineage fusion in G alápagos giant tortoisesNARA Subscribed
Although many classic radiations on islands are thought to be the result of repeated lineage splitting, the role of past fusion is rarely known because during these events, purebreds are rapidly replaced by a swarm of admixed individuals. Here, we capture lineage fusion in action in a Galápagos giant tortoise species, Chelonoidis becki , from Wolf Volcano (Isabela Island). The long generation time of Galápagos tortoises and de...
Aim To understand the relative importance of ecological and historical factors in structuring terrestrial vertebrate assemblages across the A ustralian arid zone, and to contrast patterns of community phylogenetic structure at a continental scale. Location Australia. Methods We present evidence from six lineages of terrestrial vertebrates (five lizard clades and one clade of marsupial mice) that have diversified in arid and se...
Aim To test the congruence of phylogeographic patterns and processes between a woodland agamid lizard ( Diporiphora australis ) and well‐studied Australian wet tropics fauna. Specifically, to determine whether the biogeographic history of D. australis is more consistent with a history of vicariance, which is common in wet tropics fauna, or with a history of dispersal with expansion, which would be expected for species occupyin...