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Global patterns and regional insights into kelp forest protection, restoration, and stewardshipNARA Subscribed
Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...
Exploring standing genetic variation for barley leaf rust resistance in Australian breeding panelNARA Subscribed
Key message A genotype-by-environment interaction analysis and haplotype mapping approach identifies novel haplo-blocks that can be combined with Rph20 for enhanced resistance against barley leaf rust. Abstract Barley ( Hordeum vulgare L . ) production worldwide is threatened by different rust diseases, particularly barley leaf rust (BLR) caused by fungus Puccinia hordei . Yet, very limited works have explored BLR resistance m...
Metastasis-directed stereotactic radiotherapy in patients with breast cancer: results of an international multicenter cohort studyNARA Subscribed
Metastasis-directed therapy (MDT) for oligometastatic breast cancer (≤ 5 metastases) has shown little effect in specific scenarios of randomized trials. Therefore, we aimed to assess outcomes after metastasis-directed stereotactic radiotherapy (SRT) in various clinical scenarios. We conducted an international retrospective cohort study in thirteen centers including breast cancer patients receiving SRT to any metastatic site. O...
Characterizing stay-green in barley across diverse environments: unveiling novel haplotypesNARA Subscribed
Key message There is variation in stay-green within barley breeding germplasm, influenced by multiple haplotypes and environmental conditions. The positive genetic correlation between stay-green and yield across multiple environments highlights the potential as a future breeding target. Abstract Barley is considered one of the most naturally resilient crops making it an excellent candidate to dissect the genetics of drought ad...
Purpose of Review Forests support most global terrestrial biodiversity and contribute to the livelihood of billions of people, but these and other benefits are in jeopardy due to global change. This leads to questions, such as how to address the challenges of global change in forest management, given the lack of knowledge and deep uncertainty about future developments. In addition, many of the impediments to implement adaptati...
G × E interactions as a basis for toxicological uncertaintyNARA Subscribed
To transfer toxicological findings from model systems, e.g. animals, to humans, standardized safety factors are applied to account for intra-species and inter-species variabilities. An alternative approach would be to measure and model the actual compound-specific uncertainties. This biological concept assumes that all observed toxicities depend not only on the exposure situation (environment = E), but also on the genetic (G)...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Assessment of concentration and distribution of total mercury and polychlorinated biphenyls in Green Bay, Wisconsin, USANARA Subscribed
Under the 1987 Great Lakes Water Quality Agreement, the lower Green Bay and Fox River estuary have been labeled as areas of concern due to the contamination of mercury and polychlorinated biphenyls (PCBs) from industrialization. These pollutants pose substantial health and environmental hazards for the Green Bay region. The PCBs reported in this region, including Aroclor 1242, are known to trigger carcinogenic responses in ani...
Heart failure (HF) is one of the most complex chronic disorders with high prevalence, mainly due to the ageing population and better treatment of underlying diseases. Prevalence will continue to rise and is estimated to reach 3% of the population in Western countries by 2025. It is the most important cause of hospitalisation in subjects aged 65 years or more, resulting in high costs and major social impact. The current “one-si...
Political and economic transitions have had substantial impacts on forest conservation. Where transitions are underway or anticipated, historical precedent and methods for systematically assessing future trends should be used to anticipate likely threats to forest conservation and design appropriate and prescient policy measures to counteract them. Myanmar is transitioning from an authoritarian, centralized state with a highly...