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Springer Nature5
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European Journal of Clinical Pharmacology4
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Oral bioavailability of microdoses and therapeutic doses of midazolam as a 2-dimensionally printed orodispersible film in healthy volunteersNARA Subscribed
European Journal of Clinical Pharmacology · 2022 · Vol. 78 · Issue 12 · Springer
Mareile H. Breithaupt; Evelyn Krohmer; Lenka Taylor; Eva Koerner; Torsten Hoppe-Tichy; Juergen Burhenne; Kathrin I. Foerster; Markus Dachtler; Gerald Huber; Rakesh Venkatesh; Karin Eggenreich; David Czock; Gerd Mikus; Antje Blank; Walter E. Haefeli
Purpose The use of two-dimensional (2D) printing technologies of drugs on orodispersible films (ODF) can promote dose individualization and facilitate drug delivery in vulnerable patients, including children. We investigated midazolam pharmacokinetics after the administration of 2D-printed ODF. Methods Midazolam doses of 0.03 and 3 mg were printed on an ODF using a 2D drug printer. We investigated the bioavailability of the tw...
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Accuracy of freely available online GFR calculators using the CKD-EPI equationNARA Subscribed
European Journal of Clinical Pharmacology · 2020 · Vol. 76 · Issue 10 · Springer
Sarah Seiberth; Theresa Terstegen; Dorothea Strobach; David Czock
Purpose Estimated glomerular filtration rate (eGFR) as calculated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is used for detection of chronic kidney disease and drug dose adjustment. The purpose of the present study was to investigate the accuracy of freely available eGFR online calculators. Methods All identified CKD-EPI online calculators were run with five reference cases differing in age, s...
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Definition of variables required for comprehensive description of drug dosage and clinical pharmacokineticsNARA Subscribed
European Journal of Clinical Pharmacology · 2017 · Vol. 73 · Issue 5 · Springer
Anna v. Medem; Hanna M. Seidling; Hans-Georg Eichler; Jens Kaltschmidt; Michael Metzner; Carina M. Hubert; David Czock; Walter E. Haefeli
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Pro-active provision of drug information as a technique to address overdosing in intensive-care patients with renal insufficiencyNARA Subscribed
European Journal of Clinical Pharmacology · 2009 · Vol. 65 · Issue 8 · Springer
Thilo Bertsche; Martina Fleischer; Johannes Pfaff; Jens Encke; David Czock; Walter E. Haefeli
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Mechanism-based pharmacokinetic–pharmacodynamic modeling of antimicrobial drug effectsNARA Subscribed
Journal of Pharmacokinetics and Pharmacodynamics · 2007 · Vol. 34 · Issue 6 · Springer
David Czock; Frieder Keller
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