Within this study, thiolated and alkenylated β-cyclodextrins were developed as novel mucoadhesive excipients capable of interacting with mucosal surfaces and prolonging the residence time of incorporated drugs at absorption sites, thereby potentially enhancing their bioavailability. For this purpose, cysteine-, cysteamine-, allylcarbamate-, and methacrylate-functionalized oligosaccharides were synthesized, and the resulting st...