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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Multichemical Exposure Assessment Using Silicone Wristbands in Central American AdolescentsNARA Subscribed
Chemical exposures are poorly characterized in Central America, where chronic kidney disease of uncertain etiology (CKDu) is a leading cause of death. Most research evaluates occupational exposures in adults, yet early-life exposures remain understudied. We used silicone wristband passive samplers to characterize exposure to over 1,500 chemicals among Nicaraguan adolescents ( n = 80) residing in CKD high-risk communities but n...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Environmental DNA (eDNA) combined with quantitative PCR analysis is a fast and accurate alternative to more costly and laborious physical methods to detect the highly invasive zebra mussel ( Dreissena polymorpha ). We have developed, in collaboration with the managing authorities of an artificial reservoir, a cost-effective eDNA qPCR-High resolution melt (HRM) assay for zebra mussel which we used for a pilot monitoring of spat...
Brightness temperature is operationally used to retrieve sea surface salinity (TB-SSS) over the global ocean, but is contaminated by land and sea ice in close proximity. Ocean color can be used to retrieve SSS (OC-SSS) via the relation between color and salinity, but this relation is only valid over the coastal ocean with terrestrial influence. Important ecological areas exist where both spectral domains can provide SSS estima...
Both local and global climate phenomena shape the hydrologic regimes of watersheds. For aridland rivers in the southwestern United States, peak flows occur during two distinct periods: spring snowmelt and summer monsoons. Although discharge ( Q ) is a primary driver of variation in the production and consumption of instream organic matter, or stream metabolism, few connection have been made regarding how climate impacts ecosys...