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Resistance to pyrethroid insecticides is a major concern for malaria vector control. Pyrethroids target the voltage‐gated sodium channel (VGSC), an essential component of the mosquito nervous system. Substitutions in the amino acid sequence can induce a resistance phenotype. We use whole‐genome sequence data from phase 2 of the Anopheles gambiae 1000 Genomes Project (Ag1000G) to provide a comprehensive account of genetic varia...
Quantifying the concentration dependence of sedimentation coefficients for globular macromolecules: a continuing age-old problemNARA Subscribed
This retrospective investigation has established that the early theoretical attempts to directly incorporate the consequences of radial dilution into expressions for variation of the sedimentation coefficient as a function of the loading concentration in sedimentation velocity experiments require concentration distributions exhibiting far greater precision than that achieved by the optical systems of past and current analytica...
We describe a human and large animal Langendorff experimental apparatus for live electrophysiological studies and measure the electrophysiological changes due to gap junction uncoupling in human and porcine hearts. The resultant ex vivo intact human and porcine model can bridge the translational gap between smaller simple laboratory models and clinical research. In particular, electrophysiological models would benefit from the...
Extreme variability in abundance of California salmon populations is often ascribed to ocean conditions, yet relatively little is known about their marine life history. To investigate which ocean conditions influence their distribution and abundance, we surveyed juvenile Chinook salmon ( Oncorhynchus tshawytscha ) within the California Current (central California [37°30′N) to Newport, Oregon (44°00′N]) for a 2‐week period over...
Region‐wide changes in marine ecosystem dynamics: state‐space models to distinguish trends from step changesNARA Subscribed
Regime shifts are sudden changes in ecosystem structure that can be detected across several ecosystem components. The concept that regime shifts are common in marine ecosystems has gained popularity in recent years. Many studies have searched for the step‐like changes in ecosystem state expected under a simple interpretation of this idea. However, other kinds of change, such as pervasive trends, have often been ignored. We ass...
Cryoconservation of South African plant genetic diversityNARA Subscribed
Persistence of a significant population of rare Canterbury mudfish ( Neochanna burrowsius ) in a hydrologically isolated catchmentNARA Subscribed
Canterbury mudfish ( Neochanna burrowsius ) are endemic to a small region of Canterbury, South Island, New Zealand and classified as nationally endangered. We reviewed data from the New Zealand Freshwater Fish Database and trapped fish in July 2006, and January and February 2007 in the Waianiwaniwa Valley, Canterbury to determine the importance of this catchment for mudfish conservation. Mudfish were found in 19 of the 28 site...
Lidar remote sensing of above‐ground biomass in three biomesNARA Subscribed
Estimation of the amount of carbon stored in forests is a key challenge for understanding the global carbon cycle, one which remote sensing is expected to help address. However, estimation of carbon storage in moderate to high biomass forests is difficult for conventional optical and radar sensors. Lidar ( li ght d etection and r anging) instruments measure the vertical structure of forests and thus hold great promise for remo...
CorrectionNARA Subscribed