The indirect effects of macroalgal biomass on coral settlement remain poorly understood, particularly on degraded inshore reefs characterised by high algal cover. We investigated how macroalgal removal influences benthic community composition and subsequent coral settlement and persistence by deploying 240 terracotta settlement tiles across experimental plots at two inshore reefs (Yunbenun, Great Barrier Reef, Australia). On e...

Rationale LQD was an open-label randomised trial comparing lithium versus quetiapine augmentation of antidepressants in treatment-resistant depression (TRD). In the primary analysis, quetiapine was more effective at reducing depressive symptoms. Objectives Conduct a secondary analysis of LQD to examine anxiolysis of Quetiapine compared to Lithium and examine baseline anxiety as a moderator of antidepressant effects. Methods Us...

Background While canonical anabolic and proteolytic pathways have been well examined in the context of skeletal muscle proteostasis, the roles of endoplasmic reticulum stress (ERS) and the induced unfolded protein response (UPR) are underappreciated. Thus, we aimed to determine whether aging and/or disuse atrophy in rats altered skeletal muscle ERS/UPR markers. Methods and Results Soleus (SOL) and plantaris (PLT) muscles of 3-...

The implementation of nature-based solutions (NbS), including living shorelines, to mitigate estuarine habitat loss is increasing at a pace exceeding the evaluation of their long-term success. Constructed oyster reefs (CORs) made of shell, concrete, stone, and other materials are one living shoreline tactic that is widely utilized, yet few studies have been conducted to understand the development of CORs within the context of...

Biodiversity and human well‐being strategies are only as good as the set of ideas people think about. We evaluated value‐focused thinking (VFT), a framework that emphasizes creating objectives and strategies that are responsive to the objectives. We performed a proof‐of‐concept study of VFT with 6 conservation planning teams at a global conservation organization. We developed a package of materials related to VFT, including me...

Pathogenic germline exonuclease domain (ED) variants of POLE and POLD1 cause the Mendelian dominant condition polymerase proof-reading associated polyposis (PPAP). We aimed to describe the clinical features of all PPAP patients with probably pathogenic variants. We identified patients with a variants mapping to the EDs of POLE or POLD1 from cancer genetics clinics, a colorectal cancer (CRC) clinical trial, and systematic revie...

Persistent, large‐area droughts are among the most damaging natural disasters, having major effects on agriculture, industry, forestry, human health and society, and ecosystems. In the Canadian Prairie provinces of the sub‐humid continental interior, changing climatic conditions, and shifts between periods of extreme wet and dry weather, emphasize the need for a better understanding of past and future variability of the region...

Aim We test macroecological hypotheses ( H1: long‐term climate stability; H2: climate seasonality; H3: climate distinctiveness or rarity; and, H4: spatial heterogeneity in contemporary climate, topography or habitat ) proposed to explain broad‐scale patterns of total species endemism. Location Continental areas worldwide and zoogeographical realms. Methods Using species distribution maps for mammals and amphibians, we calculat...