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Seven-year experience (2018–2025) of a hospital-based cardiovascular tissue bank in Israel: operational insights and clinical impactNARA Subscribed
Cryopreserved human heart valves and cardiovascular tissues (homografts) are essential for the surgical treatment of congenital and acquired valvular diseases, particularly in pediatric patients, where prosthetic options are limited. To address the clinical demand for high-quality grafts in Israel, Sheba Medical Center, the largest tertiary care hospital in Israel, established a Good Manufacturing Practice (GMP) compliant Card...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
The Fraction of Carbon in Soil Organic Matter as a National‐Scale Soil Process IndicatorNARA Subscribed
Soil organic matter (SOM) is an important component of ecosystem carbon stocks. Generally, SOM found in mineral and organo‐mineral soils can be categorised into two fractions: particulate organic matter (POM) and mineral‐associated‐organic matter (MAOM), both of which contain soil organic carbon (SOC). Understanding the relationship between SOC and SOM fractions provides insight into SOM decomposition and SOC storage potential...
Comparing the efficacy of two antibiotic cocktails in decontamination of cardiovascular tissuesNARA Subscribed
Cardiovascular allografts are essential for patients with severe cardiovascular diseases. Yet, microbial contamination of the grafts poses a life-threatening risk to recipients. Tissue banks utilize various decontamination methods during cardiovascular tissue processing, often involving antibiotic solutions. This study compares the efficacy of an in-house prepared antibiotic cocktail (tissue bank cocktail) and a commercially a...
Background Erythropoietin-producing hepatocellular (EPH) receptors are the largest known family of receptor tyrosine kinases characterized in humans. These proteins are involved in tissue organization, synaptic plasticity, vascular development and the progression of various diseases including cancer. The Erythropoietin-producing hepatocellular receptor tyrosine kinase member EphB6 is a pseudokinase which has not attracted an e...
Some combinatorics of data leakage induced by clustersNARA Subscribed
Data leakage is a common issue that can lead to misleading generalisation error estimation and incorrect hyperparameter tuning. However, its mechanisms are not always well understood. In this work, we consider the case of clustered data and investigate the distribution of the number of elements in leakage when the data set is uniformly split. For both the validation and test sets, the first and second moments of the number of...
Chung-Jansen syndrome is a neurodevelopmental disorder characterized by intellectual disability, behavioral problems, obesity and dysmorphic features. It is caused by pathogenic variants in the PHIP gene that encodes for the Pleckstrin homology domain-interacting protein, which is part of an epigenetic modifier protein complex. Therefore, we hypothesized that PHIP haploinsufficiency may impact genome-wide DNA methylation (DNAm...
Functional connectivity correlates of reduced goal-directed behaviors in behavioural variant frontotemporal dementiaNARA Subscribed
We explored the resting state functional connectivity correlates of apathy assessed as a multidimensional construct, using behavioral metrics, in behavioral variant frontotemporal dementia (bvFTD). We recorded the behavior of 20 bvFTD patients and 16 healthy controls in a close-to-real-life situation including a free phase (FP—in which actions were self-initiated) and a guided phase (GP—in which initiation of actions was facil...
Coral reefs are in global decline due to climate change and anthropogenic influences (Hughes et al., Conservation Biology , 27: 261–269, 2013). Near coastal cities or other densely populated areas, coral reefs face a range of additional challenges. While considerable progress has been made in understanding coral responses to acute individual stressors (Dominoni et al., Nature Ecology & Evolution , 4: 502–511, 2020), the impact...
Pre‐Columbian fisheries catch reconstruction for a subtropical estuary in South AmericaNARA Subscribed
Small‐scale fisheries provide food and livelihoods for thousands of people along the Brazilian coastline. However, considerable uncertainties still surround the extent to which artisanal and subsistence fisheries contribute to the total of national landings and their historical ecological significance. Fisheries monitoring is deficient in Brazil, and historical records are limited to irregular accounts spanning the last few de...