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Tenacibaculosis, a disease caused by Tenacibaculum spp., is of concern in British Columbia (BC, Canada) due to the potential for interspecific transmission from Atlantic salmon ( Salmo salar L.) to Pacific salmon. However, the susceptibility of most Pacific salmonids remains unknown. In this study, Atlantic salmon post‐smolts were bath‐exposed to an Atlantic salmon‐derived BC isolate of Tenacibaculum maritimum (isolate 2.1C) a...
Soil Microbial Diversity and Network Organization Respond to Land Use and Agricultural Inputs WorldwideNARA Subscribed
Soil microbiomes are critical for ecosystem functioning, yet the global influences of climate and agricultural practices on their diversity and structure remain incompletely characterized. Here we analyzed 1921 soil samples from 33 countries worldwide across diverse biomes to assess how climate gradients and agricultural inputs, including pesticides and fertilizers, shape prokaryotic and fungal communities. We found that micro...
Groundwater-based water services as complex socio-hydrogeological systems: insights from Vietnam’s Mekong DeltaNARA Subscribed
Groundwater systems are critical to global water security, yet the complex interactions between household coping strategies, resource sustainability, and climate change remain difficult to govern. This study applies qualitative systems mapping to characterise socio-hydrogeological dynamics in Vietnam’s Mekong Delta, a region currently facing intensifying saline intrusion and rapid land-use change. Drawing on a household survey...
Main conclusion A haplotype-resolved, chromosome-scale AAC Mountainview sainfoin genome sequence along with organelle assemblies, methylome, and comparative tissue/stress-specific transcriptomes provide a solid foundation to support downstream sainfoin breeding efforts. Abstract Sainfoin ( Onobrychis viciifolia Scop.) is an outcrossing, perennial forage crop valued for its leguminous nature, nutritional quality, palatability,...
Local Angler Knowledge Reveals Declines in Fishing Quality for Black Bass in Lakes of Eastern OntarioNARA Subscribed
Local ecological knowledge can be useful to assess data‐limited fisheries such as the Ontario Black Bass ( Micropterus spp.) recreational fishery. We surveyed local anglers using the Life History Calendar approach to determine if there were perceived changes in fishing quality for Black Bass in eastern Ontario across different time periods. For both species (Largemouth Bass and Smallmouth Bass), respondents noted declines in n...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Small Molecules to Elevate Rab7-GTPase Activity and Lower Cholesterol Accumulation in Niemann-Pick Type C DiseaseNARA Subscribed
Purpose Niemann-Pick type C (NPC) disease caused by mutations in cholesterol transporters NPC1 or NPC2 is characterized by cholesterol accumulation in late endosomes/lysosomes (LE/Lys). The activation of alternative cholesterol export routes that can bypass NPC1/2 deficiency could provide therapeutic opportunities. We previously demonstrated that gene depletion of the Rab7-GTPase activating protein (GAP) TBC1D15, which hydroly...